Recent developments and highlights in biomarkers in allergic diseases and asthma

被引:83
作者
Eguiluz-Gracia, Ibon [1 ]
Tay, Tunn Ren [2 ]
Hew, Mark [3 ,4 ]
Escribese, Maria M. [5 ,6 ]
Barber, Domingo [5 ]
O'Hehir, Robyn E. [3 ,7 ]
Torres, Maria J. [1 ,8 ]
机构
[1] Hosp Reg Univ Malaga, IBIMA, Unidad Alergia, UMA,ARADyAL, Malaga, Spain
[2] Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore
[3] Alfred Hosp, Allergy Asthma & Clin Immunol Serv, Melbourne, Vic, Australia
[4] Monash Univ, Sch Publ Hlth Prevent Med, Melbourne, Vic, Australia
[5] Univ San Pablo CEU, Inst Med Mol Aplicada, Fac Med, Madrid, Spain
[6] Univ San Pablo CEU, Fac Med, Dept Ciencias Med Basicas, Madrid, Spain
[7] Monash Univ, Cent Clin Sch, Dept Allergy Clin Immunol & Resp Med, Melbourne, Vic, Australia
[8] Andalusian Ctr Nanomed & Biotechnol BIONAND, Malaga, Spain
关键词
asthma; biomarkers; chronic rhinosinusitis; drug hypersensitivity; food allergy; EXHALED BREATH CONDENSATE; IMPLEMENTATION CONSORTIUM GUIDELINES; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; STEVENS-JOHNSON SYNDROME; BASOPHIL ACTIVATION TEST; INNATE LYMPHOID-CELLS; HLA-B GENOTYPE; CHRONIC RHINOSINUSITIS; ORAL IMMUNOTHERAPY; SERUM PERIOSTIN;
D O I
10.1111/all.13628
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The potential of precision medicine in allergy and asthma has only started to be explored. A significant clarification in the pathophysiology of rhinitis, chronic rhinosinusitis, asthma, food allergy and drug hypersensitivity was made in the last decade. This improved understanding led to a better classification of the distinct phenotypes and to the discovery of new drugs such as biologicals, targeting phenotype-specific mechanisms. Nevertheless, many conditions remain poorly understood such as non-eosinophilic airway diseases or non-IgE-mediated food allergy. Moreover, there is a need to predict the response to specific therapies and the outcome of drug and food provocations. The identification of patients at risk of progression towards severity is also an unmet need in order to establish adequate preventive or therapeutic measures. The implementation of precision medicine in the clinical practice requires the identification of phenotype-specific markers measurable in biological matrices. To become useful, these biomarkers need to be quantifiable by reliable systems, and in samples obtained in an easy, rapid and cost-efficient way. In the last years, significant research resources have been put in the identification of valid biomarkers for asthma and allergic diseases. This review summarizes these recent advances with focus on the biomarkers with higher clinical applicability.
引用
收藏
页码:2290 / 2305
页数:16
相关论文
共 165 条
[41]   A systematic review of fractional exhaled nitric oxide in the routine management of childhood asthma [J].
Gomersal, Tim ;
Harnan, Sue ;
Essat, Munira ;
Tappenden, Paul ;
Wong, Ruth ;
Lawson, Rod ;
Pavord, Ian ;
Everard, Mark Lloyd .
PEDIATRIC PULMONOLOGY, 2016, 51 (03) :316-328
[42]   The clinical and immunological effects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions [J].
Gomez, F. ;
Bogas, G. ;
Gonzalez, M. ;
Campo, P. ;
Salas, M. ;
Diaz-Perales, A. ;
Rodriguez, M. J. ;
Prieto, A. ;
Barber, D. ;
Blanca, M. ;
Torres, M. J. ;
Mayorga, C. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (03) :339-350
[43]   Characterisation of asthma subgroups associated with circulating YKL-40 levels [J].
Gomez, Jose L. ;
Yan, Xiting ;
Holm, Carole T. ;
Grant, Nicole ;
Liu, Qing ;
Cohn, Lauren ;
Nezgovorova, Vera ;
Meyers, Deborah A. ;
Bleecker, Eugene R. ;
Crisafi, Gina M. ;
Jarjour, Nizar N. ;
Rogers, Linda ;
Reibman, Joan ;
Chupp, Geoffrey L. .
EUROPEAN RESPIRATORY JOURNAL, 2017, 50 (04)
[44]   Dermatophagoides pteronyssinus immunotherapy changes the T-regulatory cell activity [J].
Gonzalez, M. ;
Dona, I. ;
Palomares, F. ;
Campo, P. ;
Rodriguez, M. J. ;
Rondon, C. ;
Gomez, F. ;
Fernandez, T. D. ;
Perkins, J. R. ;
Escribese, M. M. ;
Torres, M. J. ;
Mayorga, C. .
SCIENTIFIC REPORTS, 2017, 7
[45]   A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research [J].
Grabenhenrich, L. B. ;
Reich, A. ;
Bellach, J. ;
Trendelenburg, V. ;
Sprikkelman, A. B. ;
Roberts, G. ;
Grimshaw, K. E. C. ;
Sigurdardottir, S. ;
Kowalski, M. L. ;
Papadopoulos, N. G. ;
Quirce, S. ;
Dubakiene, R. ;
Niggemann, B. ;
Fernandez-Rivas, M. ;
Ballmer-Weber, B. ;
van Ree, R. ;
Schnadt, S. ;
Mills, E. N. C. ;
Keil, T. ;
Beyer, K. .
ALLERGY, 2017, 72 (03) :453-461
[46]   Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial [J].
Green, RH ;
Brightling, CE ;
McKenna, S ;
Hargadon, B ;
Parker, D ;
Bradding, P ;
Wardlaw, AJ ;
Pavord, ID .
LANCET, 2002, 360 (9347) :1715-1721
[47]   Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis [J].
Hagan, John B. ;
Laidlaw, Tanya M. ;
Divekar, Rohit ;
O'Brien, Erin K. ;
Kita, Hirohito ;
Volcheck, Gerald W. ;
Hagan, Christina R. ;
Lal, Devyani ;
Teaford, Harry G., III ;
Erwin, Patricia J. ;
Zhang, Nan ;
Rank, Matthew A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2017, 5 (04) :990-+
[48]   Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma [J].
Haldar, Pranabashis ;
Brightling, Christopher E. ;
Hargadon, Beverley ;
Gupta, Sumit ;
Monteiro, William ;
Sousa, Ana ;
Marshall, Richard P. ;
Bradding, Peter ;
Green, Ruth H. ;
Wardlaw, Andrew J. ;
Pavord, Ian D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (10) :973-984
[49]   Exploring the Effects of Omalizumab in Allergic Asthma An Analysis of Biomarkers in the EXTRA Study [J].
Hanania, Nicola A. ;
Wenzel, Sally ;
Rosen, Karin ;
Hsieh, Hsin-Ju ;
Mosesova, Sofia ;
Choy, David F. ;
Lal, Preeti ;
Arron, Joseph R. ;
Harris, Jeffrey M. ;
Busse, William .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (08) :804-811
[50]   Associations between blood eosinophils and decline in lung function among adults with and without asthma [J].
Hancox, Robert J. ;
Pavord, Ian D. ;
Sears, Malcolm R. .
EUROPEAN RESPIRATORY JOURNAL, 2018, 51 (04)