Efficacy and safety of azathioprine during remission of immune-mediated thrombotic thrombocytopenic purpura

被引：5

作者：

Bichard, Christian ^{[1
]}

Mancini, Ilaria ^{[2
,3
]}

Agosti, Pasquale ^{[2
,3
]}

Capecchi, Marco ^{[4
,5
]}

De Leo, Pasqualina ^{[4
]}

Arcudi, Sara ^{[2
,3
]}

Ferrari, Barbara ^{[4
]}

Trisolini, Silvia Maria ^{[6
]}

Longu, Francesco ^{[7
]}

Fozza, Claudio ^{[8
]}

Artoni, Andrea ^{[4
]}

Peyvandi, Flora ^{[2
,3
,4
]}

机构：

[1] Univ Milan, Milan, Italy

[2] Univ Milan, Dept Pathophysiol & Transplantat, Via Pace 9, I-20122 Milan, Italy

[3] Fdn Luigi Villa, Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy

[5] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[6] Sapienza Univ, Dept Translat & Precis Med, Hematol, Rome, Italy

[7] Azienda Osped Univ, Sassari, Italy

[8] Univ Sassari, Dept Med Surg & Expt Sci, Sassari, Italy

来源：

BLOOD ADVANCES | 2022年 / 6卷 / 18期

关键词：

ADAMTS13; TTP; THERAPY; PHARMACOLOGY; CONSENSUS; FEATURES; OUTCOMES; RELAPSE;

D O I：

10.1182/bloodadvances.2022007632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：5463 / 5466

页数：4

共 24 条

[1] Thrombotic thrombocytopenic purpura: Toward targeted therapy and precision medicine [J].

Coppo, Paul ;

Cuker, Adam ;

George, James N. .

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2019, 3 (01) :26-37

[2] Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor [J].

Crawley, James T. B. ;

de Groot, Rens ;

Xiang, Yaozu ;

Luken, Brenda M. ;

Lane, David A. .

BLOOD, 2011, 118 (12) :3212-3221

[3] Redefining outcomes in immune TTP: an international working group consensus report [J].

Cuker, Adam ;

Cataland, Spero R. ;

Coppo, Paul ;

de la Rubia, Javier ;

Friedman, Kenneth D. ;

George, James N. ;

Knoebl, Paul N. ;

Hovinga, Johanna A. Kremer ;

Laemmle, Bernhard ;

Matsumoto, Masanori ;

Pavenski, Katerina ;

Peyvandi, Flora ;

Sakai, Kazuya ;

Sarode, Ravi ;

Thomas, Mari R. ;

Tomiyama, Yoshiaki ;

Veyradier, Agnes ;

Westwood, John-Paul ;

Scully, Marie .

BLOOD, 2021, 137 (14) :1855-1861

[4] Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura [J].

Hie, Miguel ;

Gay, Julie ;

Galicier, Lionel ;

Provot, Francois ;

Presne, Claire ;

Poullin, Pascale ;

Bonmarchand, Guy ;

Wynckel, Alain ;

Benhamou, Ygal ;

Vanhille, Philippe ;

Servais, Aude ;

Bordessoule, Dominique ;

Coindre, Jean-Philippe ;

Hamidou, Mohamed ;

Vernant, Jean-Paul ;

Veyradier, Agnes ;

Coppo, Paul .

BLOOD, 2014, 124 (02) :204-210

[5] Survival and relapse in patients with thrombotic thrombocytopenic purpura [J].

Hovinga, Johanna A. Kremer ;

Vesely, Sara K. ;

Terrell, Deirdra R. ;

Laemmle, Bernhard ;

George, James N. .

BLOOD, 2010, 115 (08) :1500-1511

[6] Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura [J].

Jestin, Matthieu ;

Benhamou, Ygal ;

Schelpe, An-Sofie ;

Roose, Elien ;

Provot, Francois ;

Galicier, Lionel ;

Hie, Miguel ;

Presne, Claire ;

Poullin, Pascale ;

Wynckel, Alain ;

Saheb, Samir ;

Deligny, Christophe ;

Servais, Aude ;

Girault, Stephane ;

Delmas, Yahsou ;

Kanouni, Tank ;

Lautrette, Alexandre ;

Chauveau, Dominique ;

Mousson, Christiane ;

Perez, Pierre ;

Halimi, Jean-Michel ;

Charvet-Rumpler, Anne ;

Hamidou, Mohamed ;

Cathebras, Pascal ;

Vanhoorelbeke, Karen ;

Veyradier, Agnes ;

Coppo, Paul .

BLOOD, 2018, 132 (20) :2143-2153

[7]

Kömhoff M, 2014, NEW ENGL J MED, V371, P1846, DOI [10.1056/NEJMc1410951, 10.1056/NEJMra1312353]

[8] Azathioprine: Association with Therapy-related Myelodysplastic Syndrome and Acute Myeloid Leukemia [J].

Kwong, Yok-Lam .

JOURNAL OF RHEUMATOLOGY, 2010, 37 (03) :485-490

[9] THE CLINICAL-PHARMACOLOGY OF 6-MERCAPTOPURINE [J].

LENNARD, L .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 43 (04) :329-339

[10] Clinical and Laboratory Features of Patients with Acquired Thrombotic Thrombocytopenic Purpura: Fourteen Years of the Milan TTP Registry [J].

Mancini, Ilaria ;

Pontiggia, Silvia ;

Pallas, Roberta ;

Artoni, Andrea ;

Valsecchi, Carla ;

Ferrari, Barbara ;

Mikovic, Danijela ;

Peyvandi, Flora ;

Trisolini, Silvia Maria ;

Capria, Saveria ;

Facchini, Luca ;

Codeluppi, Katia ;

Rinaldi, Erminia ;

Pastore, Domenico ;

Campus, Simona ;

Podda, Rosa Anna ;

Caria, Cinzia ;

Caddori, Aldo ;

Nicolosi, Daniela ;

Giuffrida, Gaetano ;

Agostini, Vanessa ;

Roncarati, Umberto ;

Mannarella, Clara ;

Fragasso, Alberto ;

Podda, Gian Marco ;

Birocchi, Simone ;

Cerbone, Anna Maria ;

Tufano, Antonella ;

Loffredo, Giuseppe ;

Menna, Giuseppe ;

Pizzuti, Michele ;

Re, Giuseppe ;

Ronchi, Michela ;

De Fanti, Alessandro ;

Amarri, Sergio ;

Defina, Marzia ;

Bocchia, Monica ;

Ceru, Silvia .

THROMBOSIS AND HAEMOSTASIS, 2019, 119 (05) :695-704

← 1 2 3 →