The angiotensin II AT2 receptor is an AT1 receptor antagonist

被引：362

作者：

AbdAlla, S

Lother, H

Abdel-tawab, AM

Quitterer, U

机构：

[1] Ain Shams Univ Hosp, Med Res Ctr, Cairo, Egypt

[2] Heinrich Pette Inst, D-20251 Hamburg, Germany

[3] Inst Pharmakol & Toxikol, D-97078 Wurzburg, Germany

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2001年 / 276卷 / 43期

关键词：

D O I：

10.1074/jbc.M105253200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vasopressor angiotensin II activates AT(1) and AT(2) receptors. Most of the known in vivo effects of angiotensin II are mediated by AT(1) receptors while the biological functions of AT(2) receptors are less clear. We report here that the AT(2) receptor binds directly to the AT(1) receptor and thereby antagonizes the function of the AT(1) receptor. The AT(1)-specific antagonism of the AT(2) receptor was independent of AT(2) receptor activation and signaling, and it was effective on different cells and on human myometrial biopsies with AT(1)/AT(2) receptor expression. Thus, the AT(2) receptor is the first identified example of a G-protein-coupled receptor which acts as a receptor-specific antagonist.

引用

页码：39721 / 39726

页数：6

共 22 条

[1] AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration [J].