Processing of the circumsporozoite protein in infected hepatocytes is not dependent on aspartic proteases

被引：12

作者：

Bongfen, S. E. ^{[1
]}

Balam, S. ^{[1
]}

Torgler, R. ^{[1
]}

Romero, J. F. ^{[1
]}

Corradin, G. ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

来源：

PARASITE IMMUNOLOGY | 2008年 / 30卷 / 6-7期

关键词：

antigen processing/presentation; circumsporozoite protein; infected hepatocytes; Plasmodium berghei;

D O I：

10.1111/j.1365-3024.2008.01032.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells play a major role in the protective immune response against the liver stage of malaria. It was previously shown that the circumsporozoite protein (CSP) is processed and presented to specific T cells by both traversed and infected hepatocytes, but their respective antigen processing requirements were not completely defined. In the present study, we show that in vitro processing of the Plasmodium berghei CSP by infected mouse primary hepatocytes is exclusively dependent on proteasomes, while aspartic proteases are also needed in the case of traversed hepatocytes.

引用

页码：375 / 378

页数：4

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