Aging, immune senescence, and immunotherapy: A comprehensive review

被引：69

作者：

Elias, Rawad ^{[1
]}

Hartshorn, Kevan ^{[2
]}

Rahma, Osama ^{[3
]}

Lin, Nina ^{[4
]}

Snyder-Cappione, Jennifer E. ^{[5
,6
]}

机构：

[1] Hartford Hosp, Hartford HealthCare Canc Inst, Hartford, CT 06115 USA

[2] Boston Univ, Sch Med, Sect Hematol Oncol, Boston, MA 02118 USA

[3] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[4] Boston Univ, Sch Med, Boston Med Ctr, Dept Med, Boston, MA 02215 USA

[5] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA

[6] Boston Univ, Sch Med, Flow Cytometry Core Facil, Boston, MA 02118 USA

来源：

SEMINARS IN ONCOLOGY | 2018年 / 45卷 / 04期

关键词：

Immunotherapy; Checkpoint inhibitors; Older adults; Immune senescence; Frailty; REGULATORY T-CELLS; ALPHA-GALACTOSYLCERAMIDE KRN7000; DENDRITIC CELLS; SUPPRESSOR-CELLS; ADVANCED MELANOMA; GAMMA-DELTA; NKT CELLS; IN-VITRO; CYTOMEGALOVIRUS-INFECTION; OLDER-ADULTS;

D O I：

10.1053/j.seminoncol.2018.08.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The advent of immune checkpoint inhibitors (ICIs) has changed the landscape of cancer treatment. Older adults represent the majority of cancer patients; however, direct data evaluating ICIs in this patient population is lacking. Aging is associated with changes in the immune system known as "immunosenescence" that could impact the efficacy and safety profile of ICIs. In this paper, we review aging -associated changes in the immune system as they may relate to cancer and immunotherapy, with mention of the effect of chronic viral infections and frailty. Furthermore, we summarize the current clinical evidence of ICI effectiveness and toxicity among older adults with cancer. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：187 / 200

页数：14

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