The Multifaceted Roles of USP7: New Therapeutic Opportunities

被引：216

作者：

Nicholson, Benjamin ^{[1
]}

Kumar, K. G. Suresh ^{[1
]}

机构：

[1] Progenra Inc, Malvern, PA 19355 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2011年 / 60卷 / 1-2期

关键词：

USP7; HAUSP; Deubiquitylase; Cancer; Ubiquitin; HERPES-SIMPLEX-VIRUS; UBIQUITIN-SPECIFIC PROTEASE; DNA-DAMAGE-RESPONSE; BETA-TRCP; GMP SYNTHETASE; EMBRYONIC LETHALITY; MDM2-DEFICIENT MICE; CHECKPOINT; ICP0; CELL;

D O I：

10.1007/s12013-011-9185-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Disclosed drug discovery programs have identified inhibitors of USP7 such as P005091 with cellular proof of concept and anti-proliferative activity in cancer models. Taken together, USP7 inhibitors hold promise as a new strategy for the treatment of disease.

引用

页码：61 / 68

页数：8

共 82 条

[31] Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: Implications for the regulation of the p53-MDM2 pathway [J].