Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin

被引：1

作者：

Fabre, C

Criddle, J

Nolder, D

Klein, JL

机构：

[1] St Thomas Hosp, Guys & St Thomas Hosp NHS Fdn Trust, Dept Infect, London SE1 7EH, England

[2] St Thomas Hosp, Guys & St Thomas Hosp NHS Fdn Trust, Dept Paediat Emergency Med, London SE1 7EH, England

[3] Univ London London Sch Hyg & Trop Med, Pathogen Mol Biol Unit, London WC1E 7HT, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2005年 / 99卷 / 11期

关键词：

malaria; Plasmodium falciparum; recrudescence; drug interaction; quinine; phenytoin;

D O I：

10.1016/j.trstmh.2005.06.009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Quinine remains a reliable treatment for falciparum malaria in most parts of the world. We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use. Supported by a subtherapeutic quinine level, we hypothesise that a drug interaction with phenytoin may compromise the efficacy of quinine in the treatment of malaria. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：871 / 873

页数：3

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