Evaluation of variation in coagulation among children with Mycoplasma pneumoniae pneumonia: a case-control study

Objective: Acute organ embolism in children with Mycoplasma pneumoniae pneumonia (MPP) has been reported, but changes in coagulation are unclear. This study aimed to investigate changes in coagulation in children with MPP. Methods: A total of 185 children with MMP (cases) and 117 healthy children (controls) were recruited. We measured prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and plasma fibrinogen (FIB) and D-dimer levels. Results: Plasma FIB (3.39 +/- 0.96 g/L vs 2.93 +/- 0.6 6g/L, t = 4.50) and D-dimer (326.45 +/- 95.62mg/L vs 263.93 +/- 103.32mg/L, t=5.36) in MPP children were higher than controls and PT (9.54 +/- 4.97S vs 11.48 +/- 5.96S, t=3.05) and APTT (31.41 +/- 12.01S vs 38.38 +/- 11.72S, t=4.95) were shorter than controls. FIB, D-dimer, PT, and APTT were not different between the high IgM-titre and low-titre groups. The areas under the receiver operating characteristic curves in cases and controls for plasma FIB and D-dimer levels were 0.654 (95% confidence interval [CI], 0.593-0.716, P = 0.031) and 0.682 (95% CI, 0.619-0.744, P = 0.032), respectively. Conclusions: Children with MPP have a higher risk of blood coagulation and thrombosis. Controlling these problems should be considered as soon as possible.