Highly efficient organic reactions "on Water", "in Water", and both

被引：187

作者：

Shapiro, Nelly ^{[1
]}

Vigalok, Arkadi ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Exact Sci, Sch Chem, IL-69978 Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 15期

关键词：

aldehydes; green chemistry; oxidation; Passerini reaction; water;

D O I：

10.1002/anie.200705347

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Wet, wet, wet: Hydrophobic aldehydes are cleanly oxidized upon stirring with water in air. Addition of hydrophobic isocyanides to aqueous suspensions of such aldehydes results in the formation of Passerini reaction products, with the aldehyde being the source of both carbonyl and ester functions. Partially watersoluble reagents reacted slower than water-insoluble ones. Isotope labeling studies show that water participates in these "on water" reactions. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2849 / 2852

页数：4

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