ACCELERATED PUBLICATION The mitochondrial citrate carrier: a new player in inflammation

被引：291

作者：

Infantino, Vittoria ^{[1
,2
]}

Convertini, Paolo ^{[1
]}

Cucci, Liana ^{[3
]}

Panaro, Maria Antonietta ^{[3
]}

Di Noia, Maria Antonietta ^{[1
,2
]}

Calvello, Rosa ^{[1
]}

Palmieri, Ferdinando ^{[1
,4
]}

Iacobazzi, Vito ^{[1
,4
]}

机构：

[1] Univ Bari, Dept Pharmacobiol, Lab Biochem & Mol Biol, I-70125 Bari, Italy

[2] Univ Basilicata, Dept Chem, I-85100 Potenza, Italy

[3] Univ Bari, Dept Human Anat & Histol, I-70124 Bari, Italy

[4] CNR Inst Biomembranes & Bioenerget, I-70125 Bari, Italy

来源：

BIOCHEMICAL JOURNAL | 2011年 / 438卷

关键词：

citrate carrier (CIC); gene regulation; immune cell; nitric oxide (NO); prostaglandin E-2; reactive oxygen species (ROS); NF-KAPPA-B; RAT-LIVER MITOCHONDRIA; TRICARBOXYLATE CARRIER; IDENTIFICATION; TRANSCRIPTION; MACROPHAGES; GENE; REGULATORS; PROTEINS;

D O I：

10.1042/BJ20111275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

引用

页码：433 / 436

页数：4

共 24 条

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