Low-density lipoprotein receptor-related protein 1: new functions for an old molecule

被引：20

作者：

Franchini, Massimo ^{[1
]}

Montagnana, Martina ^{[2
]}

机构：

[1] Azienda Osped Univ Parma, Dipartimento Patol & Med Lab, Serv Immunoematol & Med Trasfus, I-43100 Parma, Italy

[2] Azienda Osped Univ Verona, Sez Biochim Clin, Verona, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2011年 / 49卷 / 06期

关键词：

endocytosis; factor VIII (FVIII); lipoprotein receptor-related protein 1 (LRP1); thrombosis; COAGULATION-FACTOR-VIII; PLASMA FACTOR-VIII; BINDING-SITE; LRP; ALPHA-2-MACROGLOBULIN; POLYMORPHISMS; CLEARANCE; RISK; PROTEASES; FAMILY;

D O I：

10.1515/CCLM.2011.154

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.

引用

页码：967 / 970

页数：4

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