Preparation and characterization of photo-oxidative dual-crosslinked chitosan/hyaluronic acid hydrogels

被引：10

作者：

Zhao, Benbo ^{[1
]}

Zhao, Mingda ^{[2
]}

Sun, Honggang ^{[1
,3
]}

Yang, Yuedi ^{[2
]}

Sun, Shixiong ^{[1
,4
]}

Yu, Heping ^{[5
]}

He, Mengmeng ^{[2
]}

Sun, Yong ^{[2
]}

Cheng, Yuan ^{[1
,4
]}

机构：

[1] North Univ China, Sch Chem Engn & Technol, Taiyuan 030051, Shanxi, Peoples R China

[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China

[3] Southwest Inst Technol & Engn, Chongqing 400039, Peoples R China

[4] Dezhou Grad Sch North Univ China, Dezhou 253034, Shandong, Peoples R China

[5] Agr Prod Proc Res Inst Chinese Acad Trop Sci, Guangdong Prov Key Lab Nat Rubber Proc, Zhanjiang 524001, Guangdong, Peoples R China

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2022年 / 180卷

基金：

中国国家自然科学基金;

关键词：

Hydrogels; Photo-crosslinked; Photo -oxidative crosslinked; Controllable; Catechol; HYALURONIC-ACID; CO-DELIVERY; CHITOSAN; CARTILAGE; TISSUE; SCAFFOLD; ADHESIVE; RELEASE; REPAIR; FILMS;

D O I：

10.1016/j.reactfunctpolym.2022.105378

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Here, photo-crosslinked CM/HM hydrogels and photo-oxidative dual-crosslinked CM/HM/CSD hydrogels (DH) were fabricated based on chitosan methacrylate (CM), aminoethyl methacrylated hyaluronic acid (HM) and chitosan-3,4-dihydroxybenzaldehyde (CSD). Two kinds of different substitution degree of CM and HM and one kind of CSD were prepared respectively by amidation. The chemical structures of CM, HM, CSD were determined using proton nuclear magnetic resonance (1H-NMR) spectroscopy, fourier transform infrared (FTIR) spectros-copy, ultraviolet-visible (UV-vis) spectrum and differential scanning calorimetry (DSC). CM/HM hydrogels and DH with adjustable properties were obtained by adjusting the degree of substitution (DS) and the type of network. These hydrogels can be easily and quickly gelled in situ and all hydrogels had desirable swelling percentages and biodegradability. Furthermore, introduction of catechins enhanced the mechanical strength of hydrogels meanwhile improved the flexibility, and maintained the pore structure. These controllable hydrogels have great potential for tissue engineering applications.

引用

页数：13

共 70 条

[1] Chitosan ascorbate hydrogel improves water uptake capacity and cell adhesion of electrospun poly(epsilon-caprolactone) membranes [J].

Augustine, Robin ;

Dan, Pan ;

Schlachet, Inbar ;

Rouxel, Didier ;

Menu, Patrick ;

Sosnik, Alejandro .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 559 :420-426

[2] Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold [J].

Bae, Min Soo ;

Yang, Dae Hyeok ;

Lee, Jung Bok ;

Heo, Dong Nyoung ;

Kwon, Yong-Dae ;

Youn, In Chan ;

Choi, Kuiwon ;

Hong, Jong Hyun ;

Kim, Gye Tae ;

Choi, Yong Suk ;

Hwang, Eui Hwan ;

Kwon, Il Keun .

BIOMATERIALS, 2011, 32 (32) :8161-8171

[3] A tough polysaccharide-based cell-laden double-network hydrogel promotes articular cartilage tissue regeneration in rabbits [J].

Baei, Payam ;

Daemi, Hamed ;

Mostafaei, Farhad ;

Sayahpour, Forough Azam ;

Baharvand, Hossein ;

Eslaminejad, Mohamadreza Baghaban .

CHEMICAL ENGINEERING JOURNAL, 2021, 418

[4] Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel [J].

Beck, Emily C. ;

Barragan, Marilyn ;

Tadros, Madeleine H. ;

Gehrke, Stevin H. ;

Detamore, Michael S. .

ACTA BIOMATERIALIA, 2016, 38 :94-105

[5] Controlled enzymatic hydrolysis and synthesis of lignin cross-linked chitosan functional hydrogels [J].

Beer, Bianca ;

Bartolome, Miguel Jimenez ;

Berndorfer, Lisa ;

Bochmann, Guenther ;

Guebitz, Georg M. ;

Nyanhongo, Gibson S. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 161 (161) :1440-1446

[6] Engineered 3D-scaffolds of photocrosslinked chitosan-gelatin hydrogel hybrids for chronic wound dressings and regeneration [J].

Carvalho, Isadora C. ;

Mansur, Herman S. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 78 :690-705

[7] In situ photocrosslinkable hyaluronic acid-based surgical glue with tunable mechanical properties and high adhesive strength [J].

Chandrasekharan, Ajeesh ;

Seong, Keum-Yong ;

Yim, Sang-Gu ;

Kim, Sodam ;

Seo, Sungbaek ;

Yoon, Jinhwan ;

Yang, Seung Yun .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2019, 57 (04) :522-530

[8] Smart Injectable Hydrogels for Cancer Immunotherapy [J].

Chao, Yu ;

Chen, Qian ;

Liu, Zhuang .

ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (02)

[9] Zein-hyaluronic acid binary complex as a delivery vehicle of quercetagetin: Fabrication, structural characterization, physicochemical stability and in vitro release property [J].

Chen, Shuai ;

Han, Yahong ;

Wang, Yingqi ;

Yang, Xi ;

Sun, Cuixia ;

Mao, Like ;

Gao, Yanxiang .

FOOD CHEMISTRY, 2019, 276 :322-332

[10] Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration [J].

Chen, Yingqi ;

Sheng, Weibei ;

Lin, Jianjing ;

Fang, Chongzhou ;

Deng, Jiapeng ;

Zhang, Peng ;

Zhou, Meng ;

Liu, Peng ;

Weng, Jian ;

Yu, Fei ;

Wang, Deli ;

Kang, Bin ;

Zeng, Hui .

ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (06) :7592-7608

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