Zebrafish models of autism spectrum disorder

被引：104

作者：

Meshalkina, Dania A. ^{[1
]}

Kizlyk, Marina N. ^{[1
]}

Kysil, Elana V. ^{[1
]}

Collier, Adam D. ^{[2
]}

Echevarria, David J. ^{[2
,3
]}

Abreu, Murilo S. ^{[4
]}

Barcellos, Leonardo J. G. ^{[4
,5
]}

Song, Cai ^{[6
,7
]}

Warnick, Jason E. ^{[8
]}

Kyzar, Evan J. ^{[9
]}

Kalueff, Allan V. ^{[1
,3
,6
,10
]}

机构：

[1] St Petersburg State Univ, Inst Translat Biomed, St Petersburg 199034, Russia

[2] Univ Southern Mississippi, Dept Psychol, Hattiesburg, MS USA

[3] Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA 70458 USA

[4] Fed Univ Santa Maria UFSM, Grad Program Pharmacol, BR-97105900 Santa Maria, RS, Brazil

[5] Univ Passo Fundo, Grad Program Bioexperimentat, BR 285, BR-99052900 Passo Fundo, RS, Brazil

[6] Guangdong Ocean Univ, Inst Marine Drugs & Nutr, Zhanjiang 330001, Peoples R China

[7] China Med Univ, Grad Inst Neural & Cognit Sci, Taichung 000001, Taiwan

[8] Arkansas Tech Univ, Dept Behav Sci, Russellville, AR 72801 USA

[9] Univ Illinois, Coll Med, Chicago, IL 60612 USA

[10] Ural Fed Univ, Ekaterinburg 620002, Russia

来源：

EXPERIMENTAL NEUROLOGY | 2018年 / 299卷

基金：

俄罗斯基础研究基金会;

关键词：

Autism spectrum disorder; Zebrafish; Behavioral models; Toxicological models; Genetic models; FRAGILE-X-SYNDROME; DANIO-RERIO; ADULT ZEBRAFISH; VALPROIC ACID; BEHAVIORAL INTERVENTION; SEROTONINERGIC SYSTEMS; NEUROSCIENCE RESEARCH; COMPARATIVE GENOMICS; SOCIAL-INTERACTION; KIN RECOGNITION;

D O I：

10.1016/j.expneurol.2017.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by motor, social and cognitive deficits that develop early during childhood. The pathogenesis of ASD is not well characterized and involves a multifaceted interaction between genetic, neurobiological and environmental factors. Animal (experimental) models possess evolutionarily conserved behaviors and molecular pathways that are highly relevant for studying ASD. The zebrafish (Danio rerio) is a relatively new animal model with promise for understanding the pathogenesis of complex brain disorders and discovering novel treatments. As a highly social and genetically tractable organism, zebrafish have recently been applied to model a variety of deficits relevant to ASD. Here, we discuss the developing utility of zebrafish models of ASD, as well as current behavioral, toxicological and genetic models of ASD, and future directions of research in this field. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：207 / 216

页数：10

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