Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats

被引：78

作者：

Diaz-Ruiz, A

Rios, C

Duarte, I

Correa, D

Guizar-Sahagun, G

Grijalva, I

Ibarra, A ^{[1
]}

机构：

[1] IMSS, CMN Siglo XXI, HE, Unidad Invest Med Enfermedades Neurol, Mexico City, DF, Mexico

[2] Ctr Invest Proyecto Camina, Lab Neuroinmunol, Mexico City, Aguascalientes, Mexico

[3] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Dept Neuroquim, Mexico City, DF, Mexico

[4] SSA, Inst Nacl Diagnost & Ref Epidemiol, Dept Biotecnol, Mexico City, DF, Mexico

来源：

NEUROSCIENCE LETTERS | 1999年 / 266卷 / 01期

关键词：

cyclosporin-A; free-radicals; inflammatory response; lipid peroxidation; neuroprotection; spinal cord injury;

D O I：

10.1016/S0304-3940(99)00255-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Besides its immunosuppresive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given du ring the fi rst 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

共 21 条

[1] OXIDATIVE STRESS DECREASES ANTIOXIDANT ENZYME-ACTIVITIES IN REAGGREGATION CULTURES OF RAT-BRAIN CELLS [J].