Transposable elements, circular RNAs and mitochondria transcription in age-related genomic regulation

被引：23
作者：
Bravo, Juan, I [1 ,2 ]
Nozownik, Severine [1 ,3 ]
Danthi, Prakroothi S. [1 ]
Benayoun, Berenice A. [1 ,4 ,5 ,6 ]
机构：
[1] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
[2] Univ Southern Calif, Grad Program Biol Aging, Los Angeles, CA 90089 USA
[3] Univ Paris Diderot Paris 7, Magistere Europeen Genet, F-75014 Paris, France
[4] Univ Southern Calif, Neurosci Grad Program, Los Angeles, CA 90089 USA
[5] USC Norris Comprehens Canc Ctr, Epigenet & Gene Regulat, Los Angeles, CA 90089 USA
[6] USC Stem Cell Initiat, Los Angeles, CA 90089 USA
来源：
DEVELOPMENT | 2020年 / 147卷 / 11期
基金：
美国国家科学基金会;
关键词：
Aging; CircRNAs; Mitochondria; Transposable elements; LIFE-SPAN; L1; RETROTRANSPOSITION; ALZHEIMERS-DISEASE; SENESCENT CELLS; INSULIN SENSITIVITY; BINDING PROTEIN; PEPTIDE HUMANIN; CERNA NETWORKS; RIBOSOMAL-RNA; ALU;
D O I：
10.1242/dev.175786
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging classes of molecules with promise as aging modulators include transposable elements, circRNAs and the mitochondria! transcriptome. Analytical complexity means that these molecules are often overlooked, even though they exhibit strong associations with aging and, in some cases, may directly contribute to its progress. Here, we review the links between these novel factors and age-related phenotypes, and we suggest tools that can be easily incorporated into existing pipelines to better understand the aging process.
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页数：18
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