Heart failure mortality in southeast Asian patient's with left ventricular systolic dysfunction

被引:17
作者
Seow, Swee-Chong [1 ,2 ]
Chai, Ping [1 ,2 ]
Lee, Yian-Ping [1 ,2 ]
Chan, Yiong-Huak [3 ]
Kwok, Bernard W. K. [4 ]
Yeo, Tiong-Cheng [1 ,2 ]
Chia, Boon-Lock [1 ,2 ]
机构
[1] Natl Univ Singapore Hosp, Dept Cardiol, Singapore 119074, Singapore
[2] Natl Univ Singapore Hosp, Inst Heart, Singapore 117548, Singapore
[3] Natl Univ Singapore, Fac Med, Biostat Unit, Singapore 117548, Singapore
[4] Natl Heart Ctr, Singapore, Singapore
关键词
southeast Asian; heart failure; mortality; prognosis; predictors;
D O I
10.1016/j.cardfail.2007.03.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Prognostic indicators and mortality in multiethnic Southeast Asian patients with heart failure (HF) may be different. Methods and Results: The study population comprised 225 inpatients with HF with a left ventricular ejection fraction of 40% or less who were discharged alive. Five years later, survival and causes of death were determined. Proportionally, more Malay and Indian patients were admitted compared with Chinese patients (P <.001). There were 55.6% in New York Heart Association (NYHA) class III or IV. Ischemic heart disease was the most common cause (85.8%). At 5 years, 152 patients (67.5%) had died. Angiotensin-converting enzyme inhibitors were prescribed to 79.1% of patients on discharge. Cardiovascular causes accounted for 69.7% of deaths. Predictors of mortality include female gender (P =.046), age 70 years or more (P =.017), renal impairment (P =.008), NYHA class III or IV (P =.03), and non-use of angiotensin-converting enzyme inhibitors (P =.005). On multivariate analysis, increasing age (P =.001) and renal impairment (P =.019) were independent predictors of all-cause mortality. Cardiovascular death was more likely with NYHA class III or IV (P =.004) and renal impairment (P =.012). Conclusion: Mortality is unusually high in this group of patients despite treatment. Greater use of evidence-based therapies in HF-management programs may arrest this trend.
引用
收藏
页码:476 / 481
页数:6
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