Synthesis, Anti-Inflammatory and Antioxidant Activities of Novel 3H-Thiazolo [4,5-b] Pyridines

被引：45

作者：

Chaban, Taras I. ^{[1
]}

Ogurtsov, Volodymyr V. ^{[1
]}

Matiychuk, Vasyl S. ^{[2
]}

Chaban, Ihor G. ^{[3
]}

Demchuk, Inna L. ^{[4
]}

Nektegayev, Ihor A. ^{[5
]}

机构：

[1] Danylo Halytsky Lviv Natl Med Univ, Dept Gen Bioinorgan Phys & Colloidal Chem, 69 Pekarska, UA-79010 Lvov, Ukraine

[2] Ivan Franko Natl Univ Lviv, Dept Organ Chem, 6 Kyryla & Mefodia, UA-79005 Lvov, Ukraine

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Chem FPGE, 69 Pekarska, UA-79010 Lvov, Ukraine

[4] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, UA-79010 Lvov, Ukraine

[5] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmacol, 69 Pekarska, UA-79010 Lvov, Ukraine

来源：

ACTA CHIMICA SLOVENICA | 2019年 / 66卷 / 01期

关键词：

Thiazolo [4,5-b]pyridines; synthesis; anti-inflammatory activity; antioxidant activity; DERIVATIVES; INFLAMMATION; DESIGN; QSAR;

D O I：

10.17344/acsi.2018.4570

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Hydroxy-7-methyl-3H-thiazolo [4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C-5 and C-6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

引用

页码：103 / 111

页数：9

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