Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

被引：22
|
作者：
Yang, Q [1 ]
Xu, JQ
Sun, YS
Li, ZG
Li, YG
Qian, XH
机构：
[1] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
[3] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期
关键词：
DNA cleavage; hydrolysis; naphthalimide; intercalator; selectivity; RNA;
D O I：
10.1016/j.bmcl.2005.11.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：803 / 806
页数：4
相关论文
共 50 条
  • [41] Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds
    Fernandes, Luciano
    Fischer, Franciele L.
    Ribeiro, Carolina W.
    Silveira, Gustavo P.
    Sa, Marcus M.
    Nome, Faruk
    Terenzi, Hernan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (16) : 4499 - 4502
  • [42] Nanoarchitectonics of Metal-Free Porous Polyketone as Photocatalytic Assemblies for Artificial Photosynthesis
    Mondal, Sujan
    Powar, Niket S.
    Paul, Ratul
    Kwon, Hyuna
    Das, Nitumani
    Wong, Bryan M.
    In, Su-Il
    Mondal, John
    ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (01) : 771 - 783
  • [43] Metal-free amino-graphdiyne for applications in electrocatalytic hydrogen evolution
    He, Feng
    Xing, Chengyu
    Xue, Yurui
    JOURNAL OF CATALYSIS, 2021, 395 : 129 - 135
  • [44] Aldehyde-induced metal-free decarboxylation of α-amino acids to synthesize N-alkyl-β-alkenyl cyclic amines with high stereoselectivity
    Zhou, Jiadi
    Liu, Huan
    Li, Zhaoyong
    Jin, Can
    Su, Weike
    TETRAHEDRON LETTERS, 2017, 58 (32) : 3174 - 3177
  • [45] Use of unprotected amino acids in metal-free tandem radical cyclization reactions: divergent synthesis of 6-alkyl/acyl phenanthridines
    Lu, Shi-Chao
    Li, Hong-Shuang
    Gong, Ya-Ling
    Wang, Xiao-Lei
    Li, Fu-Rong
    Li, Fei
    Duan, Gui-Yun
    Xu, Shu
    RSC ADVANCES, 2017, 7 (88): : 55891 - 55896
  • [46] Vinyl Cation Stabilization by Silicon Enables a Formal Metal-Free α-Arylation of Alkyl Ketones
    Pons, Amandine
    Michalland, Jean
    Zawodny, Wojciech
    Chen, Yong
    Tona, Veronica
    Maulide, Nuno
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (48) : 17303 - 17306
  • [47] Photoinduced Metal-Free Decarboxylative Transformations: Rapid Access to Amines, Alkyl Halides, and Olefins
    Luo, Jia-jing
    Jing, Dong
    Lu, Cong
    Zheng, Ke
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 26 (14)
  • [48] Protonated Porphyrins: Bifunctional Catalysts for the Metal-Free Synthesis of N-Alkyl-Oxazolidinones
    Cavalleri, Matteo
    Damiano, Caterina
    Manca, Gabriele
    Gallo, Emma
    CHEMISTRY-A EUROPEAN JOURNAL, 2023, 29 (01)
  • [49] Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones
    Yin, Hui
    Jian, Siqi
    Feng, Xiujuan
    Bao, Ming
    Zhang, Xuan
    ORGANIC CHEMISTRY FRONTIERS, 2024, 11 (11) : 3124 - 3130
  • [50] Direct and selective metal-free N6-arylation of adenosine residues for simple fluorescence labeling of DNA and RNA
    Ravi Kumara, Guralamatta Siddappa
    Pandith, Anup
    Seo, Young Jun
    CHEMICAL COMMUNICATIONS, 2021, 57 (44) : 5450 - 5453
12345