Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

被引：22
|
作者：
Yang, Q [1 ]
Xu, JQ
Sun, YS
Li, ZG
Li, YG
Qian, XH
机构：
[1] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
[3] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期
关键词：
DNA cleavage; hydrolysis; naphthalimide; intercalator; selectivity; RNA;
D O I：
10.1016/j.bmcl.2005.11.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：803 / 806
页数：4
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