Fructose-fused γ-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands

被引：22

作者：

Araujo, Ana C. ^{[2
,3
]}

Nicotra, Francesco ^{[1
]}

Costa, Barbara ^{[1
]}

Giagnoni, Gabriella ^{[1
]}

Cipolla, Laura ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biosci & Biotechnol, I-20126 Milan, Italy

[2] Univ Lisbon, Dept Quim & Bioquim, P-1749016 Lisbon, Portugal

[3] CQB, P-1749016 Lisbon, Portugal

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 10-11期

关键词：

C-glycosides; fructose; gamma-butyrolactones; gamma-butyrolactams; GABA receptors;

D O I：

10.1016/j.carres.2008.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABA(A) receptors. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1840 / 1848

页数：9

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