Evolution of Osteocrin as an activity-regulated factor in the primate brain

被引：108

作者：

Ataman, Bulent ^{[1
]}

Boulting, Gabriella L. ^{[1
]}

Harmin, David A. ^{[1
]}

Yang, Marty G. ^{[1
]}

Baker-Salisbury, Mollie ^{[1
]}

Yap, Ee-Lynn ^{[1
]}

Malik, Athar N. ^{[1
]}

Mei, Kevin ^{[1
]}

Rubin, Alex A. ^{[1
]}

Spiegel, Ivo ^{[1
]}

Durresi, Ershela ^{[1
]}

Sharma, Nikhil ^{[1
]}

Hu, Linda S. ^{[1
]}

Pletikos, Mihovil ^{[2
,3
]}

Griffith, Eric C. . ^{[1
]}

Partlow, Jennifer N. ^{[4
]}

Stevens, Christine R. ^{[5
]}

Adli, Mazhar ^{[6
]}

Chahrour, Maria ^{[7
]}

Sestan, Nenad ^{[2
,3
]}

Walsh, Christopher A. ^{[4
]}

Berezovskii, Vladimir K. ^{[1
]}

Livingstone, Margaret S. ^{[1
]}

Greenberg, Michael E. ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA

[2] Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA

[3] Yale Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA

[4] Harvard Med Sch, Boston Childrens Hosp, Div Genet & Genom, Boston, MA 02115 USA

[5] Broad Inst & Harvard, Cambridge, MA 02142 USA

[6] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22903 USA

[7] Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, MvDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

来源：

NATURE | 2016年 / 539卷 / 7628期

关键词：

DIFFERENTIAL EXPRESSION ANALYSIS; GENE-EXPRESSION; CORTICAL INHIBITION; CEREBRAL-CORTEX; STRIATE CORTEX; VISUAL-CORTEX; STEM-CELLS; NEURONS; TRANSCRIPTION; ENHANCERS;

D O I：

10.1038/nature20111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species-or clade-specific activity-regulated genes that control features of brain development and function. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. We find that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2. In addition, we demonstrate that OSTN is expressed in primate neocortex and restricts activity-dependent dendritic growth in human neurons. These findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates.

引用

页码：242 / +

页数：23

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