Accelerated epigenetic aging in Down syndrome

被引：353

作者：

Horvath, Steve ^{[1
,2
]}

Garagnani, Paolo ^{[3
,4
,5
]}

Bacalini, Maria Giulia ^{[3
,4
,6
]}

Pirazzini, Chiara ^{[3
,4
]}

Salvioli, Stefano ^{[3
,4
]}

Gentilini, Davide ^{[7
]}

Di Blasio, Anna Maria ^{[7
]}

Giuliani, Cristina ^{[8
]}

Tung, Spencer ^{[9
,10
]}

Vinters, Harry V. ^{[9
,10
]}

Franceschi, Claudio ^{[4
,11
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Human Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Biostat, Los Angeles, CA 90095 USA

[3] Univ Bologna, Dept Expt Diagnost & Specialty Med, I-40126 Bologna, Italy

[4] Univ Bologna, Interdept Ctr L Galvani, I-40126 Bologna, Italy

[5] CNR, Appl Biomed Res Ctr, S Orsola Malpighi Polyclin, I-40138 Bologna, Italy

[6] Personal Genom Srl, I-37134 Verona, Italy

[7] Ist Auxol Italiano IRCCS, Ctr Res & Biomed Technol, I-20095 Milan, Italy

[8] Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy

[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[10] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[11] IRCCS, Inst Neurol Sci Bologna, I-40139 Bologna, Italy

来源：

AGING CELL | 2015年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

biomarker of aging; DNA methylation; Down syndrome; epigenetics; DNA METHYLATION; GENE-EXPRESSION; TRISOMY-21; DISEASE; MODEL; AGE;

D O I：

10.1111/acel.12325

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6years, P=7.0x10(-14)).

引用

页码：491 / 495

页数：5

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