Impact of exercise on hippocampal neurogenesis in hyperglycemic diabetes

被引：2

作者：

Lee, Chae-Bin ^{[1
]}

Baek, Seung-Soo ^{[1
]}

机构：

[1] Sangmyung Univ, Coll Art & Culture, Dept Sport & Hlth Care, 20 Hongjimun 2 Gil, Seoul 03016, South Korea

来源：

JOURNAL OF EXERCISE REHABILITATION | 2020年 / 16卷 / 02期

关键词：

Diabetes; Hyperglycemia; Neurogenesis; Cognitive impairment; Exercise; AEROBIC EXERCISE; PLASTICITY; ADULTS; BRAIN; RISK;

D O I：

10.12965/jer.2040210.105

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Hyperglycemic diabetes is a chronic metabolic disorder characterized by high level of plasma glucose. Numerous studies have shown that hyperglycemic diabetes leads to brain dysfunction including cognitive impairment and emotional disorders. This study evaluated the impact of exercise on brain dysfunction, hippocampal neurogenesis, and cognitive impairment in hyperglycemic diabetes. The present study suggests that exercise improves hyperglycemic control and prevents decline of cognition through increasing hippocampal neurogenesis. Understanding the mechanism of exercise for hippocampal neurogenesis can lead to the development of therapeutic strategies for metabolic disorders.

引用

页码：115 / 117

页数：3

共 22 条

[1] Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes [J].

Agrawal, Rahul ;

Zhuang, Yumei ;

Cummings, Bethany P. ;

Stanhope, Kimber L. ;

Graham, James L. ;

Havel, Peter J. ;

Gomez-Pinilla, Fernando .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2014, 1842 (09) :1313-1323

[2] Treadmill exercise ameliorates symptoms of Alzheimer disease through suppressing microglial activation-induced apoptosis in rats [J].

Baek, Seung-Soo ;

Kim, Sang-Hoon .

JOURNAL OF EXERCISE REHABILITATION, 2016, 12 (06) :526-534

[3] Role of exercise on the brain [J].

Baek, Seung-Soo .

JOURNAL OF EXERCISE REHABILITATION, 2016, 12 (05) :380-385

[4] Can Lifestyle Interventions Do More Than Reduce Diabetes Risk? Treating Depression in Adults With Type 2 Diabetes With Exercise and Cognitive Behavioral Therapy [J].

de Groot, Mary ;

Doyle, Todd ;

Kushnick, Michael ;

Shubrook, Jay ;

Merrill, Jennifer ;

Rabideau, Erin ;

Schwartz, Frank .

CURRENT DIABETES REPORTS, 2012, 12 (02) :157-166

[5] Metabolic Alterations Associated to Brain Dysfunction in Diabetes [J].

Duarte, Joao M. N. .

AGING AND DISEASE, 2015, 6 (05) :304-321

[6] Treadmill exercise ameliorates disturbance of spatia learning ability in scopolamine-induced amnesia rats [J].

Heo, Yu-Mi ;

Shin, Mal-Soon ;

Kim, Su-Hyun ;

Kim, Tae-Wook ;

Baek, Sang-Bin ;

Baek, Seung-Soo .

JOURNAL OF EXERCISE REHABILITATION, 2014, 10 (03) :155-161

[7] Effects of diabetes on hippocampal neurogenesis: Links to cognition and depression [J].

Ho, Nancy ;

Sommers, Marilyn S. ;

Lucki, Irwin .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2013, 37 (08) :1346-1362

[8] Treadmill exercise inhibits apoptotic neuronal cell death with suppressed vascular endothelial growth factor expression in the retinas of the diabetic rats [J].

Ji, Eun-Sang ;

Ko, Il-Gyu ;

Cho, Jung-Wan ;

Davis, Ronald W. ;

Hwang, Gwang-Yon ;

Jee, Yong-Seok ;

Lim, Baek-Vin .

JOURNAL OF EXERCISE REHABILITATION, 2013, 9 (03) :348-353

[9] Treadmill exercise ameliorates Alzheimer disease-associated memory loss through the Wnt signaling pathway in the streptozotocin-induced diabetic rats [J].

Kim, Dae-Young ;

Jung, Sun-Young ;

Kim, Kijeong ;

Kim, Chang-Ju .

JOURNAL OF EXERCISE REHABILITATION, 2016, 12 (04) :276-283

[10] Postnatal treadmill exercise alleviates short-term memory impairment by enhancing cell proliferation and suppressing apoptosis in the hippocampus of rat pups born to diabetic rats [J].

Kim, Young Hoon ;

Sung, Yun-Hee ;

Lee, Hee-Hyuk ;

Ko, Il-Gyu ;

Kim, Sung-Eun ;

Shin, Mal-Soon ;

Kim, Bo-Kyun .

JOURNAL OF EXERCISE REHABILITATION, 2014, 10 (04) :209-217

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