Effects of diet on brain iron levels among healthy individuals: an MRI pilot study

被引:20
作者
Hagemeier, Jesper [1 ]
Tong, Olivia [1 ]
Dwyer, Michael G. [1 ]
Schweser, Ferdinand [1 ,2 ]
Ramanathan, Murali [3 ]
Zivadinov, Robert [1 ,2 ]
机构
[1] SUNY Buffalo, Buffalo Neuroimaging Anal Ctr, Sch Med & Biomed Sci, Dept Neurol, Buffalo, NY 14203 USA
[2] SUNY Buffalo, MRI Clin & Translat Res Ctr, Sch Med & Biomed Sci, Buffalo, NY 14203 USA
[3] SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14203 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Diet; Nutrition; Brain iron; SWI; Phase imaging; DEEP-GRAY-MATTER; MULTIPLE-SCLEROSIS; DEFICIENCY; AGE; CONSUMPTION; ABSORPTION; DEPOSITION; GENDER; WOMEN;
D O I
10.1016/j.neurobiolaging.2015.01.010
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Increased brain iron levels may be a risk factor for age-related neurologic disorders. Little is known about factors other than age and sex potentially affecting brain iron concentration. We investigated dietary habits (iron and calcium supplements, dairy products, vegetables, and red meat) as a potential modifiable predictor of brain iron levels using 3-T susceptibility-weighted magnetic resonance imaging. One hundred ninety volunteers were scanned, and mean phase and mean phase of low-phase voxels were determined for deep gray-matter (DGM) structures, including the caudate, putamen, thalamus, pulvinar, hippocampus, amygdala, red nucleus, and substantia nigra. There was a trend for lower mean phase (suggestive of high iron levels) in individuals taking iron supplements (p = 0.075). Among men, both increased dairy and vegetable intakes were significantly associated with lower DGM mean phase (p < 0.05) and mean phase of low-phase voxels (p < 0.05) in the thalamus, pulvinar, and red nucleus. In contrast, among women, iron levels were not associated with dairy consumption (p > 0.05) in the DGM but were inversely associated with vegetable intake in the thalamus (p = 0.006). Brain iron levels appear to be modulated by diet, with effects being highly dependent on gender. Published by Elsevier Inc.
引用
收藏
页码:1678 / 1685
页数:8
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