A New Thiosemicarbazone-Based Fluorescence "Turn-on" Sensor for Zn2+ Recognition with a Large Stokes Shift and its Application in Live Cell Imaging

被引：24

作者：

Tang, Lijun ^{[1
]}

Huang, Zhenlong ^{[1
,2
]}

Zheng, Zhuxuan ^{[1
]}

Zhong, Keli ^{[1
]}

Bian, Yanjiang ^{[1
]}

机构：

[1] Bohai Univ, Dept Chem, Jinzhou 121013, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2016年 / 26卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Thiosemicarbazone; Zn2+ sensor; Fluorescence; ANTITUMOR-ACTIVITY; RIBONUCLEOTIDE REDUCTASE; ANION RECOGNITION; AQUEOUS-SOLUTION; METAL-IONS; ZINC; COMPLEXES; COPPER; BIS(THIOSEMICARBAZONE); DERIVATIVES;

D O I：

10.1007/s10895-016-1827-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Selective fluorescence turn on Zn2+ sensor with long-wavelength emission and a large Stokes shift is highly desirable in Zn2+ sensing area. We reported herein the synthesis and Zn2+ recognition properties of a new thiosemicarbazone-based fluorescent sensor L. L displays high selectivity and sensitivity toward Zn2+ over other metal ions in DMSO-H2O (1:1, v/v, HEPES 10 mM, pH = 7.4) solution with a long-wavelength emission at 572 nm and a large Stokes shift of 222 nm. Confocal fluorescence microscopy experiments demonstrate that L is cell-permeable and capable of monitoring intracellular Zn2+.

引用

页码：1535 / 1540

页数：6

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