Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials

被引:56
作者
Baniasadi, Hossein [1 ]
Madani, Zahraalsadat [1 ]
Ajdary, Rubina [2 ]
Rojas, Orlando J. [2 ,3 ,4 ]
Seppala, Jukka [1 ]
机构
[1] Aalto Univ, Sch Chem Engn, Polymer Technol, Kemistintie 1, Espoo 02150, Finland
[2] Aalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, POB 16300, FIN-00076 Espoo, Finland
[3] Univ British Columbia, Bioprod Inst, Dept Chem & Biol Engn, Dept Chem, 2360 East Mall, Vancouver, BC V6T 1Z3, Canada
[4] Univ British Columbia, Dept Wood Sci, 2360 East Mall, Vancouver, BC V6T 1Z3, Canada
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 130卷
基金
芬兰科学院;
关键词
Direct ink writing; Cellulose nanofibrils; Polyvinyl alcohol; Hydrogels; Shear-thinning; CELLULOSE NANOFIBRILS; POLY(VINYL ALCOHOL); IN-VITRO; FABRICATION; CURCUMIN; CHITOSAN; NANOPARTICLES; NANOCRYSTALS; COMPOSITES; SCAFFOLDS;
D O I
10.1016/j.msec.2021.112424
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW). The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes. The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity. After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%). The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications. As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 degrees C (similar to 80% for 8 h). Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
引用
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页数:12
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