Stem cells as biological heart pacemakers

被引:15
作者
Gepstein, L
机构
[1] Technion Israel Inst Technol, Sohnis Family Res Lab Regenerat Funct Myocardium, Dept Physiol & Biophys, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
[2] Rappaport Family Inst Res Med Sci, Sohnis Family Res Lab Regenerat Funct Myocardium, Dept Physiol & Biophys, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
基金
以色列科学基金会;
关键词
arrhythmia therapy; biological pacemakers; bradyarrhythmias; cell therapy; gene therapy; ionic channels; stem cells;
D O I
10.1517/14712598.5.12.1531
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Abnormalities in the pacemaker function of the heart or in cardiac impulse conduction may result in the appearance of a slow heart rate, traditionally requiring the implantation of a permanent electronic pacemaker. in recent years, a number of experimental approaches have been developed in an attempt to generate biological alternatives to implantable electronic devices. These strategies include, initially, a number of gene therapy approaches (aiming to manipulate the expression of ionic currents or their modulators and thereby convert quiescent cardiomyocytes into pacemaking cells) and, more recently, the use of cell therapy and tissue engineering. The latter approach explored the possibility of grafting pacemaking cells, either derived directly during the differentiation of human embryonic stem cells or engineered from mesenchymal stem cells, into the myocardium. This review will describe each of these approaches, focusing mainly on the stem cell strategies, their possible advantages and shortcomings, as well as the avenues required to make biological pacemaking a clinical reality.
引用
收藏
页码:1531 / 1537
页数:7
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