Emerging concepts of laser-activated nanoparticles for tissue bonding

被引:29
作者
Matteini, Paolo [1 ]
Ratto, Fulvio [1 ]
Rossi, Francesca [1 ]
Pini, Roberto [1 ]
机构
[1] Italian Natl Res Council, Inst Appl Phys Nello Carrara, I-50019 Sesto Fiorentino, Italy
关键词
laser; tissue repair; exogenous chromophores; nanoparticles; nanocomposites; ASSISTED VASCULAR ANASTOMOSIS; ENHANCED THERMAL-STABILITY; GOLD NANORODS; INDOCYANINE GREEN; IN-VITRO; CONTRAST AGENTS; CELLULAR UPTAKE; BYPASS-SURGERY; NANOSHELLS; SHAPE;
D O I
10.1117/1.JBO.17.1.010701
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We report recent achievements and future perspectives of minimally invasive bonding of biological tissues triggered by laser light. In particular, we review new advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions. Advanced concepts of laser tissue bonding involving the application of hybrid nanocomposites obtained by inclusion of nanochromophores into biopolymer scaffolds are also introduced. The perspectives of tissue bonding are discussed in the following aspects: (1) tissue bonding with highly-stabilized nanochromophores, (2) enhanced tissue bonding with patterned nanocomposites, (3) real-time monitoring of temperature distributions, (4) tracking of tissue regeneration based on the optical resonances of gold nanoparticles. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.1.010701]
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页数:9
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