IN VITRO AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ESSENTIAL OILS, INCLUDING HINOKITIOL

被引：0

作者：

Fujisaki, Ryuichi ^{[2
]}

Kamei, Kiyoko ^{[3
]}

Yamamura, Mariko ^{[2
]}

Nishiya, Hajime ^{[2
]}

Inouye, Shigeharu ^{[1
]}

Takahashi, Miki ^{[1
]}

Abe, Shigeru ^{[1
]}

机构：

[1] Teikyo Univ, Inst Med Mycol, Hachioji, Tokyo 1920395, Japan

[2] Teikyo Univ Hosp, Tokyo, Japan

[3] Teikyo Univ, Sch Med, Dept Parasitol, Tokyo 173, Japan

来源：

SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH | 2012年 / 43卷 / 02期

关键词：

anitplasmodial activity; essential oils; in vitro; in vivo; ANTIMALARIAL ACTIVITY; VOLATILE COMPONENTS; LEAVES;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 mu g/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.

引用

页码：270 / 279

页数：10

共 17 条

[1] Artemisinin, a novel antimalarial drug: Biochemical and molecular approaches for enhanced production [J].