Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: Controlled clinical pilot study with 19 patients

被引：13

作者：

Irifune, Kazunori ^{[1
]}

Hamada, Hironobu ^{[1
,3
]}

Ito, Ryoji ^{[1
]}

Katayama, Hitoshi ^{[1
,2
]}

Watanabe, Akira

Kato, Aki ^{[1
]}

Miyoshi, Seigo ^{[1
]}

Hamaguchi, Naohiko ^{[1
]}

Toyozawa, Ryo ^{[1
]}

Hamaguchi, Sachiko ^{[1
]}

Abe, Masahiro

Nishimura, Kazutaka

Higaki, Jitsuo ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Integrated Med & Informat, Toon, Ehime 7910295, Japan

[2] Uwajima City Hosp, Dept Resp Med, Uwajima, Ehime, Japan

[3] Hiroshima Univ, Grad Sch Hlth Sci, Dept Hlth & Sports Med Sci, Hiroshima, Japan

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 8-9期

关键词：

PIPC; Bakumondoto; Medicine; Fixed herbal kampo medicine; Cough;

D O I：

10.1016/j.phymed.2011.02.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bakumondoto (TJ-29) is a traditional herbal medicine that has been used in Japan for the treatment of bronchitis, bronchial asthma, and cough. This study investigated the effect of TJ-29 for the treatment of post-infectious prolonged cough. We performed a multicenter randomized controlled trial treating patients without (group A. n=11) or with TJ-29 (group B. n=8) for a total of 2 weeks using a beta 2 stimulant as the basal agent. Efficacy and safety were compared by a cough diary, VAS and sleeping questionnaire. At 4 and 5days after treatment, the cough score of group B showed significant improvement compared with group A, demonstrating an early antitussive effect. At the assessment 2 weeks after treatment start, both groups showed similar levels of improvement in the cough score. No significant difference was observed in the VAS and the sleeping questionnaire items. In conclusion, oral TJ-29 administration could be useful and safe for the treatment of post-infectious prolonged cough. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：630 / 633

页数：4

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