Antibody therapy for COVID-19

被引：15

作者：

Hammarstrom, Lennart ^{[1
]}

Marcotte, Harold ^{[2
]}

Piralla, Antonio ^{[3
]}

Baldanti, Fausto ^{[3
,4
]}

Pan-Hammarstrom, Qiang ^{[1
]}

机构：

[1] Karolinska Inst, NEO, Dept Biosci & Nutr, Huddinge, Sweden

[2] Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Div Clin Immunol & Transfus Med, Stockholm, Sweden

[3] Fdn IRCCS Policlin San Matteo, Microbiol & Virol Dept, Pavia, Italy

[4] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2021年 / 21卷 / 06期

基金：

瑞典研究理事会; 欧盟地平线“2020”;

关键词：

COVID-19; hyperimmunoglobulin; monoclonal antibodies; plasma therapy; CONVALESCENT PLASMA THERAPY; ACUTE RESPIRATORY SYNDROME; SPIKE PROTEIN; SARS-COV-2;

D O I：

10.1097/ACI.0000000000000787

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review To provide an update of the current state of antibody therapy for Severe Acute Respiratory Syndrome Coronavirus 2 infection that has progressed immensely in a very short time period. Recent findings Limited clinical effect of classical passive immunotherapy (plasma therapy, hyperimmune immunoglobulin [IgG] preparations) whereas monoclonal antibody therapy, if initiated early in the disease process, shows promising results. Summary Although antibody therapy still remains to be fully explored in patients with COVID-19, a combination of IgG monoclonal antibodies against the receptor-binding domain of the spike protein currently appears to provide the best form of antibody therapy, Immunoglobulin A dimers and Immunoglobulin M pentamers also show promising preliminary therapeutic results.

引用

页码：553 / 558

页数：6

共 45 条

[1] Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study [J].

Abolghasemi, Hassan ;

Eshghi, Peyman ;

Cheraghali, Abdol Majid ;

Fooladi, Abbas Ali Imani ;

Moghaddam, Farzaneh Bolouki ;

Imanizadeh, Sina ;

Maleki, Matin Moeini ;

Ranjkesh, Mohammad ;

Rezapour, Mohammad ;

Bahramifar, Ali ;

Einollahi, Behzad ;

Hosseini, Mohammad Javad ;

Jafari, Nematollah Joneidi ;

Nikpouraghdam, Mohamad ;

Sadri, Nariman ;

Tazik, Mokhtar ;

Sali, Shanaz ;

Okati, Shamsi ;

Askari, Elham ;

Tabarsi, Payam ;

Aslani, Jafar ;

Sharifipour, Ehsan ;

Jarahzadeh, Mohammad Hossein ;

Khodakarim, Nastaran ;

Salesi, Mahmood ;

Jafari, Ramezan ;

Shahverdi, Samira .

TRANSFUSION AND APHERESIS SCIENCE, 2020, 59 (05)

[2] Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) [J].

Agarwal, Anup ;

Mukherjee, Aparna ;

Kumar, Gunjan ;

Chatterjee, Pranab ;

Bhatnagar, Tarun ;

Malhotra, Pankaj .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 371

[3] Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia [J].

Arabi, Yaseen M. ;

Hajeer, Ali H. ;

Luke, Thomas ;

Raviprakash, Kanakatte ;

Balkhy, Hanan ;

Johani, Sameera ;

Al-Dawood, Abdulaziz ;

Al-Qahtani, Saad ;

Al-Omari, Awad ;

Al-Hameed, Fahad ;

Hayden, Frederick G. ;

Fowler, Robert ;

Bouchama, Abderrezak ;

Shindo, Nahoko ;

Al-Khairy, Khalid ;

Carson, Gail ;

Taha, Yusri ;

Sadat, Musharaf ;

Alahmadi, Mashail .

EMERGING INFECTIOUS DISEASES, 2016, 22 (09) :1554-1561

[4] Targeting potential drivers of COVID-19: Neutrophil extracellular traps [J].

Barnes, Betsy J. ;

Adrover, Jose M. ;

Baxter-Stoltzfus, Amelia ;

Borczuk, Alain ;

Cools-Lartigue, Jonathan ;

Crawford, James M. ;

Dassler-Plenker, Juliane ;

Guerci, Philippe ;

Huynh, Caroline ;

Knight, Jason S. ;

Loda, Massimo ;

Looney, Mark R. ;

McAllister, Florencia ;

Rayes, Roni ;

Renaud, Stephane ;

Rousseau, Simon ;

Salvatore, Steven ;

Schwartz, Robert E. ;

Spicer, Jonathan D. ;

Yost, Christian C. ;

Weber, Andrew ;

Zuo, Yu ;

Egeblad, Mikala .

JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (06)

[5] Autoantibodies against type I IFNs in patients with life-threatening COVID-19 [J].

Bastard, Paul ;

Rosen, Lindsey B. ;

Zhang, Qian ;

Michailidis, Eleftherios ;

Hoffmann, Hans-Heinrich ;

Zhang, Yu ;

Dorgham, Karim ;

Philippot, Quentin ;

Rosain, Jeremie ;

Beziat, Vivien ;

Manry, Jeremy ;

Shaw, Elana ;

Haljasmagi, Liis ;

Peterson, Part ;

Lorenzo, Lazaro ;

Bizien, Lucy ;

Trouillet-Assant, Sophie ;

Dobbs, Kerry ;

de Jesus, Adriana Almeida ;

Belot, Alexandre ;

Kallaste, Anne ;

Catherinot, Emilie ;

Tandjaoui-Lambiotte, Yacine ;

Le Pen, Jeremie ;

Kerner, Gaspard ;

Bigio, Benedetta ;

Seeleuthner, Yoann ;

Yang, Rui ;

Bolze, Alexandre ;

Spaan, Andras N. ;

Delmonte, Ottavia M. ;

Abers, Michael S. ;

Aiuti, Alessandro ;

Casari, Giorgio ;

Lampasona, Vito ;

Piemonti, Lorenzo ;

Ciceri, Fabio ;

Bilguvar, Kaya ;

Lifton, Richard P. ;

Vasse, Marc ;

Smadja, David M. ;

Migaud, Melanie ;

Hadjadj, Jerome ;

Terrier, Benjamin ;

Duffy, Darragh ;

Quintana-Murci, Lluis ;

van de Beek, Diederik ;

Roussel, Lucie ;

Vinh, Donald C. ;

Tangye, Stuart G. .

SCIENCE, 2020, 370 (6515) :423-+

[6]

Casciola-Rosen Livia, 2020, medRxiv, DOI 10.1101/2020.10.13.20211664

[7] SARS-CoV-2 specific T-cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex vivo ELISpot assay [J].

Cassaniti, Irene ;

Percivalle, Elena ;

Bergami, Federica ;

Piralla, Antonio ;

Comolli, Giuditta ;

Bruno, Raffaele ;

Vecchia, Marco ;

Sambo, Margherita ;

Colaneri, Marta ;

Zuccaro, Valentina ;

Benazzo, Marco ;

Robotti, Carlo ;

Calastri, Anna ;

Maiorano, Eugenia ;

Ferrari, Alessandro ;

Cambie, Giuseppe ;

Baldanti, Fausto .

CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (07) :1029-1034

[8] SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 [J].

Chen, Peter ;

Nirula, Ajay ;

Heller, Barry ;

Gottlieb, Robert L. ;

Boscia, Joseph ;

Morris, Jason ;

Huhn, Gregory ;

Cardona, Jose ;

Mocherla, Bharat ;

Stosor, Valentina ;

Shawa, Imad ;

Adams, Andrew C. ;

Van Naarden, Jacob ;

Custer, Kenneth L. ;

Shen, Lei ;

Durante, Michael ;

Oakley, Gerard ;

Schade, Andrew E. ;

Sabo, Janelle ;

Patel, Dipak R. ;

Klekotka, Paul ;

Skovronsky, Daniel M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (03) :229-237

[9] Use of convalescent plasma therapy in SARS patients in Hong Kong [J].

Cheng, Y ;

Wong, R ;

Soo, YOY ;

Wong, WS ;

Lee, CK ;

Ng, MHL ;

Chan, P ;

Wong, KC ;

Leung, CB ;

Cheng, G .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2005, 24 (01) :44-46

[10] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice [J].

De Gasparo, Raoul ;

Pedotti, Mattia ;

Simonelli, Luca ;

Nickl, Petr ;

Muecksch, Frauke ;

Cassaniti, Irene ;

Percivalle, Elena ;

Lorenzi, Julio C. C. ;

Mazzola, Federica ;

Magri, Davide ;

Michalcikova, Tereza ;

Haviernik, Jan ;

Honig, Vaclav ;

Mrazkova, Blanka ;

Polakova, Natalie ;

Fortova, Andrea ;

Tureckova, Jolana ;

Iatsiuk, Veronika ;

Di Girolamo, Salvatore ;

Palus, Martin ;

Zudova, Dagmar ;

Bednar, Petr ;

Bukova, Ivana ;

Bianchini, Filippo ;

Mehn, Dora ;

Nencka, Radim ;

Strakova, Petra ;

Pavlis, Oto ;

Rozman, Jan ;

Gioria, Sabrina ;

Sammartino, Jose Camilla ;

Giardina, Federica ;

Gaiarsa, Stefano ;

Pan-Hammarstrom, Qiang ;

Barnes, Christopher O. ;

Bjorkman, Pamela J. ;

Calzolai, Luigi ;

Piralla, Antonio ;

Baldanti, Fausto ;

Nussenzweig, Michel C. ;

Bieniasz, Paul D. ;

Hatziioannou, Theodora ;

Prochazka, Jan ;

Sedlacek, Radislav ;

Robbiani, Davide F. ;

Ruzek, Daniel ;

Varani, Luca .

NATURE, 2021, 593 (7859) :424-+

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