Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters

被引：106

作者：

Duan, Hai-Feng

Xie, Jian-Hua

Qiao, Xiang-Chen

Wang, Li-Xin

Zhou, Qi-Lin ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 23期

关键词：

alpha-ketoester; alcohols; asymmetric catalysis; boronic acids; rhodium;

D O I：

10.1002/anie.200800423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Figure Presented) Rhodium catalysis: The first example of a catalytic asymmetric addition of arylboronic acids to α-ketoesters was realized by using a chiral RhI-spirophosphite ligand complex in aqueous solvent to provide tertiary α-hydroxyesters in good yields with high enantioselectivities (see scheme; DCE = 1,2-dichloroethane). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4351 / 4353

页数：3

共 54 条

[51] Design of C2-symmetric tetrahydropentalenes as new chiral diene ligands for highly enantioselective Rh-catalyzed arylation of N-tosylarylimines with arylboronic acids [J].