SEOM-GEINO clinical guideline of systemic therapy and management of brain central nervous system metastases (2021)

被引：4

作者：

Martinez-Garcia, Maria ^{[1
,2
]}

Servitja Tormo, Sonia ^{[1
]}

Vilarino Quintela, Noelia ^{[3
]}

Arance Fernandez, Ana ^{[4
]}

Berrocal Jaime, Alfonso ^{[5
]}

Cantos Sanchez de Ibarguen, Blanca ^{[6
]}

Del Barco Berron, Sonia ^{[7
]}

Garcia Campelo, Rosario ^{[8
]}

Girones Sarrio, Regina ^{[9
]}

Manuel Sepulveda-Sanchez, Juan ^{[10
]}

机构：

[1] Hosp Mar, Dept Med Oncol, Barcelona, Spain

[2] CIOCC HM Delfos, Barcelona, Spain

[3] Inst Catala Oncol L Hosp, Dept Med Oncol, Barcelona, Spain

[4] Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain

[5] Consorcio Hosp Gen Univ Valencia, Dept Med Oncol, Valencia, Spain

[6] Hosp Univ Puerta Hierro Majadahonda, Dept Med Oncol, Madrid, Spain

[7] Hosp Univ Dr Josep Trueta, Dept Med Oncol, ICO, Girona, Spain

[8] Complexo Hosp Univ A Coruna CHUAC, Dept Med Oncol, La Coruna, Spain

[9] Hosp Univ & Politecn La Fe, Dept Med Oncol, Valencia, Spain

[10] Hosp Univ, Dept Med Oncol, Madrid, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2022年 / 24卷 / 04期

关键词：

Brain metastasis; Blood-brain barrier; Targeted therapies; Immunotherapy; Guidelines; CELL LUNG-CANCER; NEGATIVE BREAST-CANCER; OPEN-LABEL; MUTANT MELANOMA; FOLLOW-UP; CRIZOTINIB; CHEMOTHERAPY; MULTICENTER; SURVIVAL; DABRAFENIB;

D O I：

10.1007/s12094-022-02803-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Central nervous system (CNS) dissemination is a severe complication in cancer and a leading cause of cancer-related mortality. Brain metastases (BMs) are the most common types of malignant intracranial tumors and are reported in approximately 25% of patients with metastatic cancers. The recent increase in incidence of BMs is due to several factors including better diagnostic assessments and the development of improved systemic therapies that have lower activity on the CNS. However, newer systemic therapies are being developed that can cross the blood-brain barrier giving us additional tools to treat BMs. The guidelines presented here focus on the efficacy of new targeted systemic therapies and immunotherapies on CNS BMs from breast, melanoma, and lung cancers.

引用

页码：703 / 711

页数：9

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