Applications of Baylis-Hillman acetates:: one-pot, facile and convenient synthesis of substituted γ-lactams

被引：80
作者：
Basavaiah, D [1 ]
Rao, JS [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 08期
关键词：
Baylis-Hillman chemistry; gamma-lactams; reductive cyclization; Fe/AcOH;
D O I：
10.1016/j.tetlet.2003.12.133
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, convenient and one-pot transformation of the acetates of Baylis-Hillman adducts into substituted gamma-lactams, that is, (E)-5-alkyl-3-arylidenepyrrolidin-2-ones via treatment with nitroalkanes in the presence of a base, followed by reductive cyclization, using Fe/AcOH, is described. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：1621 / 1625
页数：5
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