How Prevalent Are Anxiety Disorders in Schizophrenia? A Meta-Analysis and Critical Review on a Significant Association

被引:375
作者
Achim, Amelie M. [1 ,2 ]
Maziade, Michel [1 ,2 ]
Raymond, Eric [1 ]
Olivier, David [3 ]
Merette, Chantal [1 ,4 ]
Roy, Marc-Andre [1 ,2 ]
机构
[1] Univ Laval Robert Giffard, Ctr Rech, Beauport, PQ G1J 2G3, Canada
[2] Univ Laval, Dept Psychiat, Quebec City, PQ G1K 7P4, Canada
[3] CSSS Energie, Shawinigan, PQ, Canada
[4] Univ Laval, Dept Stat, Quebec City, PQ G1K 7P4, Canada
基金
加拿大健康研究院;
关键词
OCD; PTSD; social anxiety; panic disorder; agoraphobia; phobia; OBSESSIVE-COMPULSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER; SCHIZOAFFECTIVE DISORDER; PSYCHIATRIC COMORBIDITY; SOCIAL ANXIETY; PANIC-ATTACKS; NONAFFECTIVE PSYCHOSIS; SYMPTOMS; SCALE; RELIABILITY;
D O I
10.1093/schbul/sbp148
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The presence of anxiety disorders (AD) in schizophrenia (SZ) is attracting increasing interest. However, published studies have yielded very broad variations in prevalence rates across studies. The current meta-analysis sought to (1) investigate the prevalence of co-occurring AD in SZ by reporting pooled prevalence rates and (2) identify potential sources of variations in reported rates that could guide our efforts to identify and treat these co-occurring disorders in patients with SZ. Methods: We performed a systematic search of studies reporting prevalence of AD in SZ and related psychotic disorders. Mean prevalence rates and 95% confidence intervals (CIs) were first computed for each disorder. We then examined the impact of potential moderators related to patient sampling or to AD assessment methods on these rates. Results: Fifty-two eligible studies were identified. Pooled prevalence rates and CIs were 12.1% (7.0%-17.1%) for obsessive-compulsive disorders, 14.9% (8.1%-21.8%) for social phobia, 10.9% (2.9%-18.8%) for generalized AD, 9.8% (4.3%-15.4%) for panic disorders, and 12.4% (4.0%-20.8%) for post-traumatic stress disorders. For all disorders, we found significant heterogeneity in rates across studies. This heterogeneity could at least partially be explained by the effect of moderator variables related to patient characteristics or assessment methods. Conclusions: AD are highly prevalent in SZ, but important variations in rates are observed between studies. This meta-analysis highlights several factors that affect risk for, or detection of AD in SZ, and could, thus, have an important impact on treatment and outcome of SZ patients.
引用
收藏
页码:811 / 821
页数:11
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