Treatment of refractory and recurrent Clostridium difficile infection

被引：68

作者：

Surawicz, Christina M. ^{[1
]}

Alexander, Jacob ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Med, Div Gastroenterol, Seattle, WA 98104 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2011年 / 8卷 / 06期

关键词：

IN-VITRO ACTIVITY; DOUBLE-BLIND; INTRAVENOUS IMMUNOGLOBULIN; EMERGENCY COLECTOMY; ANTIBODY-RESPONSE; CONTROLLED-TRIAL; ORAL VANCOMYCIN; FUSIDIC ACID; CASE SERIES; TOXIN-A;

D O I：

10.1038/nrgastro.2011.59

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The incidence of Clostridium difficile infection (CDI) has increased since 2000, with greater numbers of severe cases reported, in part due to the emergence of a hypervirulent strain. Initial therapy with metronidazole is still recommended for mild to moderate CDI, but vancomycin is recommended for first-line therapy of severe CDI. Colectomy could be life-saving for some patients with severe disease that does not respond to maximal medical therapy. Recurrent CDI is a challenge to treat; no single effective therapy currently exists. Treatments include antibiotics, adjunct probiotics, fecal microbiota transplant and immune approaches. This Review discusses the various therapeutic approaches used for the treatment of refractory and recurrent CDI.

引用

页码：330 / 339

页数：10

共 105 条

[71] Metronidazole resistance in Clostridium difficile is heterogeneous [J].

Pelaez, T. ;

Cercenado, E. ;

Alcala, L. ;

Marin, M. ;

Martin-Lopez, A. ;

Martinez-Alarcon, J. ;

Catalan, P. ;

Sanchez-Somolinos, M. ;

Bouza, E. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (09) :3028-3032

[72] Reassessment of Clostridium difficile susceptibility to metronidazole and vancomycin [J].

Peláez, T ;

Alcalá, L ;

Alonso, R ;

Rodríguez-Créixems, M ;

García-Lechuz, JM ;

Bouza, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1647-1650

[73] Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada [J].

Pépin, J ;

Alary, ME ;

Valiquette, L ;

Raiche, E ;

Ruel, J ;

Fulop, K ;

Godin, D ;

Bourassa, C .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (11) :1591-1597

[74] Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003:: a changing pattern of disease severity [J].

Pépin, J ;

Valiquette, L ;

Alary, ME ;

Villemure, P ;

Pelletier, A ;

Forget, K ;

Pépin, K ;

Chouinard, D .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (05) :466-472

[75] Vancomycin for the treatment of Clostridium difficile infection:: For whom is this expensive bullet really magic? [J].

Pepin, Jacques .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (10) :1493-1498

[76] The effect of probiotics on Clostridium difficile diarrhea [J].

Pochapin, M .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (01) :S11-S13

[77] PROSPECTIVE-STUDY OF CLOSTRIDIUM-DIFFICILE INTESTINAL COLONIZATION AND DISEASE FOLLOWING SINGLE-DOSE ANTIBIOTIC-PROPHYLAXIS IN SURGERY [J].

PRIVITERA, G ;

SCARPELLINI, P ;

ORTISI, G ;

NICASTRO, G ;

NICOLIN, R ;

DELALLA, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (01) :208-210

[78] Incidence of Clostridium difficile infection in inflammatory bowel disease [J].

Rodemann, Joseph F. ;

Dubberke, Erik R. ;

Reske, Kimberly A. ;

Seo, Da Hea ;

Stone, Christian D. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (03) :339-344

[79] Fecal Flora Reconstitution for Recurrent Clostridium difficile Infection: Results and Methodology [J].

Rohlke, Faith ;

Surawicz, Christina M. ;

Stollman, Neil .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2010, 44 (08) :567-570

[80] Intravenous immunoglobulin therapy for severe Clostridium difficile colitis [J].

Salcedo, J ;

Keates, S ;

Pothoulakis, C ;

Warny, M ;

Castagliuolo, I ;

LaMont, JT ;

Kelly, CP .

GUT, 1997, 41 (03) :366-370

← 2 3 4 5 6 7 8 9 10 11 →