Treatment of refractory and recurrent Clostridium difficile infection

被引：68

作者：

Surawicz, Christina M. ^{[1
]}

Alexander, Jacob ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Med, Div Gastroenterol, Seattle, WA 98104 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2011年 / 8卷 / 06期

关键词：

IN-VITRO ACTIVITY; DOUBLE-BLIND; INTRAVENOUS IMMUNOGLOBULIN; EMERGENCY COLECTOMY; ANTIBODY-RESPONSE; CONTROLLED-TRIAL; ORAL VANCOMYCIN; FUSIDIC ACID; CASE SERIES; TOXIN-A;

D O I：

10.1038/nrgastro.2011.59

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The incidence of Clostridium difficile infection (CDI) has increased since 2000, with greater numbers of severe cases reported, in part due to the emergence of a hypervirulent strain. Initial therapy with metronidazole is still recommended for mild to moderate CDI, but vancomycin is recommended for first-line therapy of severe CDI. Colectomy could be life-saving for some patients with severe disease that does not respond to maximal medical therapy. Recurrent CDI is a challenge to treat; no single effective therapy currently exists. Treatments include antibiotics, adjunct probiotics, fecal microbiota transplant and immune approaches. This Review discusses the various therapeutic approaches used for the treatment of refractory and recurrent CDI.

引用

页码：330 / 339

页数：10

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