Biomarkers as diagnostic tests for delayed graft function in kidney transplantation

被引：8
作者：
Lai, Christina [1 ,2 ]
Yee, Seow Yeing [3 ]
Ying, Tracey [1 ,2 ]
Chadban, Steve [1 ,2 ]
机构：
[1] Royal Prince Alfred Hosp, Renal Med, Sydney, NSW, Australia
[2] Univ Sydney, Charles Perkins Ctr, Kidney Node, Sydney, NSW, Australia
[3] Hosp Kuala Lumpur, Nephrol Dept, Kuala Lumpur, Malaysia
来源：
TRANSPLANT INTERNATIONAL | 2021年 / 34卷 / 12期
关键词：
biomarkers; delayed graft function; kidney transplantation; GELATINASE-ASSOCIATED LIPOCALIN; CYSTATIN C; PREDICTIVE BIOMARKERS; OXIDATIVE STRESS; RENAL-FUNCTION; EARLY POSTTRANSPLANT; MACHINE PERFUSION; INJURY MOLECULE-1; TISSUE INHIBITOR; BIOPSY SPECIMENS;
D O I：
10.1111/tri.14132
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Delayed graft function (DGF) after kidney transplantation is associated with inferior outcomes and higher healthcare costs. DGF is currently defined as the requirement for dialysis within seven days post-transplant; however, this definition is subjective and nonspecific. Novel biomarkers have potential to improve objectivity and enable earlier diagnosis of DGF. We reviewed the literature to describe the range of novel biomarkers previously studied to predict DGF. We identified marked heterogeneity and low reporting quality of published studies. Among the novel biomarkers, serum NGAL had the greatest potential as a biomarker to predict DGF, but requires further assessment and validation through larger scale studies of diagnostic test performance. Given inadequacies in the dialysis-based definition, coupled with the high incidence and impact of DGF, such studies should be pursued.
引用
收藏
页码：2431 / 2441
页数：11
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