Biomarkers as diagnostic tests for delayed graft function in kidney transplantation

被引：8
作者：
Lai, Christina [1 ,2 ]
Yee, Seow Yeing [3 ]
Ying, Tracey [1 ,2 ]
Chadban, Steve [1 ,2 ]
机构：
[1] Royal Prince Alfred Hosp, Renal Med, Sydney, NSW, Australia
[2] Univ Sydney, Charles Perkins Ctr, Kidney Node, Sydney, NSW, Australia
[3] Hosp Kuala Lumpur, Nephrol Dept, Kuala Lumpur, Malaysia
来源：
TRANSPLANT INTERNATIONAL | 2021年 / 34卷 / 12期
关键词：
biomarkers; delayed graft function; kidney transplantation; GELATINASE-ASSOCIATED LIPOCALIN; CYSTATIN C; PREDICTIVE BIOMARKERS; OXIDATIVE STRESS; RENAL-FUNCTION; EARLY POSTTRANSPLANT; MACHINE PERFUSION; INJURY MOLECULE-1; TISSUE INHIBITOR; BIOPSY SPECIMENS;
D O I：
10.1111/tri.14132
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Delayed graft function (DGF) after kidney transplantation is associated with inferior outcomes and higher healthcare costs. DGF is currently defined as the requirement for dialysis within seven days post-transplant; however, this definition is subjective and nonspecific. Novel biomarkers have potential to improve objectivity and enable earlier diagnosis of DGF. We reviewed the literature to describe the range of novel biomarkers previously studied to predict DGF. We identified marked heterogeneity and low reporting quality of published studies. Among the novel biomarkers, serum NGAL had the greatest potential as a biomarker to predict DGF, but requires further assessment and validation through larger scale studies of diagnostic test performance. Given inadequacies in the dialysis-based definition, coupled with the high incidence and impact of DGF, such studies should be pursued.
引用
收藏
页码：2431 / 2441
页数：11
相关论文
共 95 条
[1]   Stem Cell Factor, Interleukin-16, and Interleukin-2 Receptor Alpha are Predictive Biomarkers for Delayed and Slow Graft Function [J].
Alachkar, N. ;
Ugarte, R. ;
Huang, E. ;
Womer, K. L. ;
Montgomery, R. ;
Kraus, E. ;
Rabb, H. .
TRANSPLANTATION PROCEEDINGS, 2010, 42 (09) :3399-3405
[2]   Urinary Exosomes as a Source of Kidney Dysfunction Biomarker in Renal Transplantation [J].
Alvarez, S. ;
Suazo, C. ;
Boltansky, A. ;
Ursu, M. ;
Carvajal, D. ;
Innocenti, G. ;
Vukusich, A. ;
Hurtado, M. ;
Villanueva, S. ;
Carreno, J. E. ;
Rogelio, A. ;
Irarrazabal, C. E. .
TRANSPLANTATION PROCEEDINGS, 2013, 45 (10) :3719-3723
[3]   TLR4 mRNA Levels as Tools to Estimate Risk for Early Posttransplantation Kidney Graft Dysfunction [J].
Andrade-Oliveira, Vinicius ;
Campos, Erika F. ;
Goncalves-Primo, Amador ;
Grenzi, Patricia C. ;
Medina-Pestana, Jose O. ;
Tedesco-Silva, Helio ;
Gerbase-DeLima, Maria .
TRANSPLANTATION, 2012, 94 (06) :589-595
[4]   Kidney injury molecule-1 staining in renal allograft biopsies 10 days after transplantation is inversely correlated with functioning proximal tubular epithelial cells [J].
Bank, Jonna R. ;
van der Pol, Pieter ;
Vreeken, Dianne ;
Monge-Chaubo, Catherine ;
Bajema, Ingeborg M. ;
Schlagwein, Nicole ;
van Gijlswijk, Danielle J. ;
van der Kooij, Sandra W. ;
Reinders, Marlies E. J. ;
de Fijter, Johan W. ;
van Kooten, Cees .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2017, 32 (12) :2132-2141
[5]   Plasma Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation and Early Renal Function Prediction [J].
Bataille, Aurelien ;
Abbas, Samia ;
Semoun, Oren ;
Bourgeois, Eric ;
Marie, Olivier ;
Bonnet, Francine ;
Resche-Rigon, Matthieu ;
Abboud, Imad ;
Losser, Marie-Reine ;
Jacob, Laurent .
TRANSPLANTATION, 2011, 92 (09) :1024-1030
[6]   THE COST-EFFECTIVE LABORATORY: IMPLEMENTATION OF ECONOMIC EVALUATION OF LABORATORY TESTING [J].
Bogavac-Stanojevic, Natasa ;
Jelic-Ivanovic, Zorana .
JOURNAL OF MEDICAL BIOCHEMISTRY, 2017, 36 (03) :238-242
[7]   Interleukin-8 Transcripts in Mononuclear Cells Determine Impaired Graft Function after Kidney Transplantation [J].
Borst, Christoffer ;
Xia, Shengqiang ;
Bistrup, Claus ;
Tepel, Martin .
PLOS ONE, 2015, 10 (02)
[8]   Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation [J].
Bromberg, Jonathan S. ;
Weir, Matthew R. ;
Gaber, A. Osama ;
Yamin, Michael A. ;
Goldberg, Itzhak D. ;
Mayne, Tracy J. ;
Cal, Weizhong ;
Cooper, Matthew .
TRANSPLANTATION, 2021, 105 (02) :443-450
[9]   Is plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) determination in donors and recipients predictive of renal function after kidney transplantation? [J].
Buemi, Antoine ;
Musuamba, Flora ;
Frederic, Stephan ;
Douhet, Anne ;
De Meyer, Martine ;
De Pauw, Luc ;
Darius, Tom ;
Kanaan, Nada ;
Wallemacq, Pierre ;
Mourad, Michel .
CLINICAL BIOCHEMISTRY, 2014, 47 (15) :68-72
[10]  
Caban A, 2009, ANN TRANSPL, V14, P10
12345678910