Pharmacokinetic variation

被引：3

作者：

Eusuf, Danielle, V ^{[1
]}

Thomas, Elizabeth ^{[2
]}

机构：

[1] North West Deanery, Anaesthesia, Manchester, Lancs, England

[2] Stockport NHS Fdn Trust, Anaesthesia & Intens Care Med, Stockport, Lancs, England

来源：

ANAESTHESIA AND INTENSIVE CARE MEDICINE | 2022年 / 23卷 / 01期

关键词：

Absorption; distribution; excretion; metabolism; pathological; pharmacodynamics; pharmacokinetics; physiological;

D O I：

10.1016/j.mpaic.2021.10.014

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Pharmacokinetics is the study of how the body handles an administered drug, including absorption, distribution, metabolism and excretion. Pharmacokinetic variation is when there is variability in the drug concentration at the effector site after administration of a standard dose. This can result in one dose of a drug being ineffective in one patient, but potentially toxic with unwanted side effects in another. There are four factors which are responsible for pharmacokinetic variation: absorption, distribution, metabolism and excretion. This article will review how physiological, pathological and pharmacological processes can influence all of these factors.

引用

页码：50 / 53

页数：4

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