pH-Triggered Drug-Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI

被引：180

作者：

Lim, Eun-Kyung ^{[2
]}

Huh, Yong-Min ^{[1
,3
,4
]}

Yang, Jaemoon ^{[1
,3
]}

Lee, Kwangyeol ^{[5
]}

Suh, Jin-Suck ^{[1
,3
,4
]}

Haam, Seungjoo ^{[2
,3
]}

机构：

[1] Yonsei Univ, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Dept Chem & Biomol Engn, Seoul 120749, South Korea

[3] YUHS KRIBB Med Convergence Res Inst, Seoul 120752, South Korea

[4] SBSI, Seoul 120752, South Korea

[5] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 21期

关键词：

BREAST-CANCER; IN-VIVO; BIOMEDICAL APPLICATIONS; CONTRAST AGENTS; FATTY ACID; DELIVERY; TUMOR; NANOCARRIERS; CHEMOTHERAPY; PLATFORM;

D O I：

10.1002/adma.201100351

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

引用

页码：2436 / +

页数：8

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