Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

被引：181

作者：

Corvera, S ^{[1
]}

Czech, MP ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01615 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(98)01366-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology - signal transduction and membrane traffic This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides was revealed novel potential interconnections between these fundamental cellular processes.

引用

页码：442 / 446

页数：5

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