Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

被引：178
作者：
Corvera, S [1 ]
Czech, MP [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01615 USA
来源：
TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 11期
关键词：
D O I：
10.1016/S0962-8924(98)01366-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology - signal transduction and membrane traffic This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides was revealed novel potential interconnections between these fundamental cellular processes.
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收藏
页码：442 / 446
页数：5
相关论文
共 58 条
  • [1] PDGF-DEPENDENT TYROSINE PHOSPHORYLATION STIMULATES PRODUCTION OF NOVEL POLYPHOSPHOINOSITIDES IN INTACT-CELLS
    AUGER, KR
    SERUNIAN, LA
    SOLTOFF, SP
    LIBBY, P
    CANTLEY, LC
    [J]. CELL, 1989, 57 (01) : 167 - 175
  • [2] Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase
    August, A
    Sadra, A
    Dupont, B
    Hanafusa, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) : 11227 - 11232
  • [3] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
    Burd, CG
    Emr, SD
    [J]. MOLECULAR CELL, 1998, 2 (01) : 157 - 162
  • [4] Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins
    Cao, XC
    Ballew, N
    Barlowe, C
    [J]. EMBO JOURNAL, 1998, 17 (08) : 2156 - 2165
  • [5] A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
    Chardin, P
    Paris, S
    Antonny, B
    Robineau, S
    BeraudDufour, S
    Jackson, CL
    Chabre, M
    [J]. NATURE, 1996, 384 (6608) : 481 - 484
  • [6] Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component ε-COP
    Daro, E
    Sheff, D
    Gomez, M
    Kreis, T
    Mellman, I
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 139 (07) : 1747 - 1759
  • [7] DARREN AE, 1997, FEBS LETT, V406, P211
  • [8] Insulin receptor internalization and signalling
    Di Guglielmo, GM
    Drake, PG
    Baass, PC
    Authier, F
    Posner, BI
    Bergeron, JJM
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 182 (1-2) : 59 - 63
  • [9] Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
    Dove, SK
    Cooke, FT
    Douglas, MR
    Sayers, LG
    Parker, PJ
    Michell, RH
    [J]. NATURE, 1997, 390 (6656) : 187 - 192
  • [10] Mechanisms and consequences of activation of protein kinase B/Akt
    Downward, J
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) : 262 - 267
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