Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands

被引：17
作者：
Ravera, Mauro [1 ]
Gabano, Elisabetta [1 ]
Sardi, Manuele [1 ]
Ermondi, Giuseppe [2 ]
Caron, Giulia [2 ]
McGlinchey, Michael J. [3 ]
Mueller-Bunz, Helge [3 ]
Monti, Elena [4 ]
Gariboldi, Marzia B. [4 ]
Osella, Domenico [1 ]
机构：
[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy
[2] Univ Torino, Ctr Innovaz, Dipartimento Sci & Tecnol Farm, CASSMedChem, I-10135 Turin, Italy
[3] Univ Coll Dublin, Sch Chem & Chem Biol, Dublin 4, Ireland
[4] Univ Insubria, Dipartimento Biol Strutturale & Funz, I-21052 Busto Arsizio, VA, Italy
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2011年 / 105卷 / 03期
关键词：
Pt(II) derivatives; X-ray diffraction; Cytotoxicity; Lipophilicity; Molecular interaction fields; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; DNA-BINDING; CISPLATIN; CYTOTOXICITY; CARBOPLATIN; OXALIPLATIN; HYDROLYSIS; MECHANISMS; TOXICOLOGY;
D O I：
10.1016/j.jinorgbio.2010.12.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis (imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：400 / 409
页数：10
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