Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

被引：2340

作者：

Meanwell, Nicholas A. ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res & Dev, Dept Med Chem, Wallingford, CT 06492 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 08期

关键词：

ADRENOCEPTOR-SELECTIVE ANTAGONISTS; CALCIUM-CHANNEL BLOCKERS; HYDROGEN-BOND BASICITY; CENTER-DOT-O; NONPROSTANOID PROSTACYCLIN MIMETICS; ALPHA-KETOHETEROCYCLIC INHIBITORS; ACTIVE NONPEPTIDIC INHIBITORS; RESPIRATORY SYNCYTIAL VIRUS; ELECTRON-WITHDRAWING POWER; OPIOID AGONIST METABOLITES;

D O I：

10.1021/jm1013693

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2529 / 2591

页数：63

共 365 条

[1] Diheteroarylmethanes .5. E-Z isomerism of carbanions substituted by 1,3-azoles: C-13 and N-15 pi-charge shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles [J].

Abbotto, A ;

Bradamante, S ;

Pagani, GA .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (05) :1761-1769

[2] Diheteroarylmethanes. 8. Mapping charge and electron-withdrawing power of the 1,2,4-triazol-5-yl substituent [J].

Abbotto, A ;

Bradamante, S ;

Facchetti, A ;

Pagani, GA .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (18) :6756-6763

[3] CHARGE MAPPING IN CARBANIONS - WEAK CHARGE DEMAND OF THE CYANO GROUP AS ASSESSED FROM A C-13 NMR-STUDY OF CARBANIONS OF ALPHA-ACTIVATED ACETONITRILES AND PHENYLACETONITRILES - BREAKDOWN OF A MYTH [J].

ABBOTTO, A ;

BRADAMANTE, S ;

PAGANI, GA .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (02) :449-455

[4] HYDROGEN-BONDING .9. SOLUTE PROTON DONOR AND PROTON ACCEPTOR SCALES FOR USE IN DRUG DESIGN [J].

ABRAHAM, MH ;

DUCE, PP ;

PRIOR, DV ;

BARRATT, DG ;

MORRIS, JJ ;

TAYLOR, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1989, (10) :1355-1375

[5] CONFORMATIONAL-ANALYSIS .22. AN NMR AND THEORETICAL INVESTIGATION OF THE GAUCHE EFFECT IN FLUOROETHANOLS [J].

ABRAHAM, RJ ;

CHAMBERS, EJ ;

THOMAS, WA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1994, (05) :949-955

[6] Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids [J].

Adelfinskaya, O. ;

Terrazas, M. ;

Froeyen, M. ;

Marliere, P. ;

Nauwelaerts, K. ;

Herdewijn, P. .

NUCLEIC ACIDS RESEARCH, 2007, 35 (15) :5060-5072

[7] Amino acid phosphoramidate nucleotides as alternative substrates for HIV-1 reverse transcriptase [J].

Adelfinskaya, Olga ;

Herdewijn, Piet .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (23) :4356-4358

[8] Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa [J].

Adler, M ;

Davey, DD ;

Phillips, GB ;

Kim, SH ;

Jancarik, J ;

Rumennik, G ;

Light, DR ;

Whitlow, M .

BIOCHEMISTRY, 2000, 39 (41) :12534-12542

[9] 1,2,5-THIADIAZOLE 1-OXIDE AND 1,1-DIOXIDE DERIVATIVES - A NEW CLASS OF POTENT HISTAMINE H2-RECEPTOR ANTAGONISTS [J].

ALGIERI, AA ;

LUKE, GM ;

STANDRIDGE, RT ;

BROWN, M ;

PARTYKA, RA ;

CRENSHAW, RR .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :210-212

[10] METHOXY GROUP NONPLANARITY IN OMICRON-DIMETHOXYBENZENES - SIMPLE PREDICTIVE MODELS FOR CONFORMATIONS AND ROTATIONAL BARRIERS IN ALKOXYAROMATICS [J].

ANDERSON, GM ;

KOLLMAN, PA ;

DOMELSMITH, LN ;

HOUK, KN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (09) :2344-2352

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