Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

被引：2275

作者：

Meanwell, Nicholas A. ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res & Dev, Dept Med Chem, Wallingford, CT 06492 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 08期

关键词：

ADRENOCEPTOR-SELECTIVE ANTAGONISTS; CALCIUM-CHANNEL BLOCKERS; HYDROGEN-BOND BASICITY; CENTER-DOT-O; NONPROSTANOID PROSTACYCLIN MIMETICS; ALPHA-KETOHETEROCYCLIC INHIBITORS; ACTIVE NONPEPTIDIC INHIBITORS; RESPIRATORY SYNCYTIAL VIRUS; ELECTRON-WITHDRAWING POWER; OPIOID AGONIST METABOLITES;

D O I：

10.1021/jm1013693

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2529 / 2591

页数：63

共 365 条

[1] Diheteroarylmethanes .5. E-Z isomerism of carbanions substituted by 1,3-azoles: C-13 and N-15 pi-charge shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles
Abbotto, A
Bradamante, S
Pagani, GA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (05) : 1761 - 1769
[2] Diheteroarylmethanes. 8. Mapping charge and electron-withdrawing power of the 1,2,4-triazol-5-yl substituent
Abbotto, A
Bradamante, S
Facchetti, A
Pagani, GA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (18) : 6756 - 6763
[3] CHARGE MAPPING IN CARBANIONS - WEAK CHARGE DEMAND OF THE CYANO GROUP AS ASSESSED FROM A C-13 NMR-STUDY OF CARBANIONS OF ALPHA-ACTIVATED ACETONITRILES AND PHENYLACETONITRILES - BREAKDOWN OF A MYTH
ABBOTTO, A
BRADAMANTE, S
PAGANI, GA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (02) : 449 - 455
[4] HYDROGEN-BONDING .9. SOLUTE PROTON DONOR AND PROTON ACCEPTOR SCALES FOR USE IN DRUG DESIGN
ABRAHAM, MH
DUCE, PP
PRIOR, DV
BARRATT, DG
MORRIS, JJ
TAYLOR, PJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1989, (10): : 1355 - 1375
[5] CONFORMATIONAL-ANALYSIS .22. AN NMR AND THEORETICAL INVESTIGATION OF THE GAUCHE EFFECT IN FLUOROETHANOLS
ABRAHAM, RJ
CHAMBERS, EJ
THOMAS, WA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1994, (05): : 949 - 955
[6] Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
Adelfinskaya, O.
Terrazas, M.
Froeyen, M.
Marliere, P.
Nauwelaerts, K.
Herdewijn, P.
[J]. NUCLEIC ACIDS RESEARCH, 2007, 35 (15) : 5060 - 5072
[7] Amino acid phosphoramidate nucleotides as alternative substrates for HIV-1 reverse transcriptase
Adelfinskaya, Olga
Herdewijn, Piet
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (23) : 4356 - 4358
[8] Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa
Adler, M
Davey, DD
Phillips, GB
Kim, SH
Jancarik, J
Rumennik, G
Light, DR
Whitlow, M
[J]. BIOCHEMISTRY, 2000, 39 (41) : 12534 - 12542
[9] 1,2,5-THIADIAZOLE 1-OXIDE AND 1,1-DIOXIDE DERIVATIVES - A NEW CLASS OF POTENT HISTAMINE H2-RECEPTOR ANTAGONISTS
ALGIERI, AA
LUKE, GM
STANDRIDGE, RT
BROWN, M
PARTYKA, RA
CRENSHAW, RR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) : 210 - 212
[10] METHOXY GROUP NONPLANARITY IN OMICRON-DIMETHOXYBENZENES - SIMPLE PREDICTIVE MODELS FOR CONFORMATIONS AND ROTATIONAL BARRIERS IN ALKOXYAROMATICS
ANDERSON, GM
KOLLMAN, PA
DOMELSMITH, LN
HOUK, KN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (09) : 2344 - 2352

← 1 2 3 4 5 6 7 8 9 10 →