Topical henna for capecitabine induced hand-foot syndrome

被引：36
作者：
Yucel, Idris [1 ]
Guzin, Gonullu [1 ]
机构：
[1] Ondokuz Mayis Univ, Sch Med, Dept Med Oncol, TR-55139 Kurupelit, Turkey
来源：
INVESTIGATIONAL NEW DRUGS | 2008年 / 26卷 / 02期
关键词：
henna; capecitabine; hand-foot;
D O I：
10.1007/s10637-007-9082-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Capecitabine is a chemotherapeutic drug for use in cancers. Hand-foot syndrome (HFS) is side effect of capecitabine which can lead the cessation of the therapy or dose reduction. Henna (Lawsonia inermis) is a traditionally used plant of Middle-East that is applied on hands and feet. Some of cancer patients in capecitabine treatment who developed HFS, we recommended to apply henna. In these patients, six patients were grade 3 HFS and four were grade 2 HFS. Complete response (CR) were seen in four of grade 3 HFS and all of grade 2; two grade 3 HFS improved to grade 1. So far, in the chemotherapy, there was no need of dose reduction and also no side effect of henna seen. Clinical improvement in these patients may relate to anti-inflammatory, antipyretic and analgesic effects of henna. Prospective studies are needed to show this therapeutic effect of henna.
引用
收藏
页码：189 / 192
页数：4
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