Molecular Mechanisms of the Action of Myricetin in Cancer

被引：26

作者：

Xie, Yutao ^{[1
]}

Wang, Yunlong ^{[1
]}

Xiang, Wei ^{[1
]}

Wang, Qiaoying ^{[2
]}

Cao, Yajun ^{[1
]}

机构：

[1] North Sichuan Med Coll Univ, Nanchong Ctr Hosp, Clin Med Coll 2, Dept Pharm, Nanchong 637000, Sichuan, Peoples R China

[2] North Sichuan Med Coll Univ, Nanchong Ctr Hosp, Clin Med Coll 2, Dept Cardiothorac Surg, Nanchong 637000, Sichuan, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 02期

关键词：

Myricetin; cancer; anticancer; molecular mechanism; natural; proliferation; angiogenesis; CELL-CYCLE ARREST; UROKINASE PLASMINOGEN-ACTIVATOR; HUMAN PERIPHERAL LYMPHOCYTES; WNT SIGNALING PATHWAY; ENDOPLASMIC-RETICULUM; ANTICANCER ACTIVITY; COLORECTAL-CANCER; PROSTATE-CANCER; POTENTIAL ROLE; INHIBITS PROLIFERATION;

D O I：

10.2174/1389557519666191018112756

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Natural compounds, such as paclitaxel and camptothecin, have great effects on the treatment of tumors. Such natural chemicals often achieve anti-tumor effects through a variety of mechanisms. Therefore, it is of great significance to conduct further studies on the anticancer mechanism of natural anticancer agents to lay a solid foundation for the development of new drugs. Myricetin, originally isolated from Myrica nagi, is a natural pigment of flavonoids that can inhibit the growth of cancer cells (such as liver cancer, rectal cancer, skin cancer and lung cancer, etc.). It can regulate many intracellular activities (such as anti-inflammatory and blood lipids regulation) and can even be bacteriostatic. The purpose of this paper is to outline the molecular pathways of the anticancer effects of myricetin, including the effect on cancer cell death, proliferation, angiogenesis, metastasis and cell signaling pathway.

引用

页码：123 / 133

页数：11

共 129 条

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