Lewis-acid catalyzed organic reactions in water.: The case of AlCl3, TiCl4, and SnCl4 believed to be unusable in aqueous medium

被引：96

作者：

Fringuelli, F ^{[1
]}

Pizzo, F ^{[1
]}

Vaccaro, L ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim, I-06123 Perugia, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 13期

关键词：

D O I：

10.1021/jo010373y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Classical Lewis acids such as AlCl3, TiCl4, and SnCl4, believed to be unusable as catalysts in aqueous medium, efficiently catalyzed regio- and stereoselective azidolysis and iodolysis of alpha,beta -epoxycarboxylic acids in water at pH 4.0 and 1.5, respectively. The concept of water-tolerant metal-salt is reexamined in direct relationship to the aqua ion hydrolysis constant.

引用

页码：4719 / 4722

页数：4

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