Superoxide radical quenching and cytochrome c peroxidase-like activity of C-60-dimalonic acid, C-62(COOH)(4)

被引：59

作者：

Okuda, K ^{[1
]}

Mashino, T ^{[1
]}

Hirobe, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/0960-894X(96)00064-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A water-soluble fullerene derivative (C-60-dimalonic acid, C-62(COOH)(4)) quenches superoxide radical (O-2(.-)), in the xanthine/xanthine oxidase system, and oxidizes reduced cyt. c in the presence of hydrogen peroxide.

引用

页码：539 / 542

页数：4

共 13 条

[1] PHOTOPHYSICAL CHARACTERIZATION AND SINGLET OXYGEN YIELD OF A DIHYDROFULLERENE [J].

ANDERSON, JL ;

AN, YZ ;

RUBIN, Y ;

FOOTE, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (21) :9763-9764

[2] PHOTOPHYSICAL PROPERTIES OF C60 [J].

ARBOGAST, JW ;

DARMANYAN, AP ;

FOOTE, CS ;

RUBIN, Y ;

DIEDERICH, FN ;

ALVAREZ, MM ;

ANZ, SJ ;

WHETTEN, RL .

JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (01) :11-12

[3] FREE-RADICAL SCAVENGING ACTIVITY OF WATER-SOLUBLE FULLERENOLS [J].

CHIANG, LY ;

LU, FJ ;

LIN, JT .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (12) :1283-1284

[4]

FRIEDMAN SH, 1993, J AM CHEM SOC, V115, P6505

[5] OXIDATION OF [60]FULLERENE BY CYTOCHROME-P450 CHEMICAL-MODELS [J].

HAMANO, T ;

MASHINO, T ;

HIROBE, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (15) :1537-1538

[6] FULLERENE CHEMISTRY IN 3 DIMENSIONS - ISOLATION OF 7 REGIOISOMERIC BISADDUCTS AND CHIRAL TRISADDUCTS OF C-60 AND DI(ETHOXYCARBONYL)METHYLENE [J].

HIRSCH, A ;

LAMPARTH, I ;

KARFUNKEL, HR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (04) :437-438

[7] WATER-SOLUBLE MALONIC-ACID DERIVATIVES OF C-60 WITH A DEFINED 3-DIMENSIONAL STRUCTURE [J].

LAMPARTH, I ;

HIRSCH, A .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (14) :1727-1728

[8] TOXICITY OF 1-METHYL-4-PHENYLPYRIDINIUM DERIVATIVES IN ESCHERICHIA-COLI [J].

MITSUMOTO, A ;

NAGANO, T ;

HIROBE, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 296 (02) :482-488

[9]

NAGANO T, 1994, CHEM PHARM BULL, V42, P2291

[10]

NAGANO T, 1989, J BIOL CHEM, V264, P9243

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