P-selectin-mediated platelet adhesion promotes tumor growth

被引：71

作者：

Qi, Cuiling ^{[1
]}

Wei, Bo ^{[2
]}

Zhou, Weijie ^{[3
]}

Yang, Yang ^{[1
]}

Li, Bin ^{[1
]}

Guo, Simei ^{[1
]}

Li, Jalin ^{[1
]}

Ye, Jie ^{[1
]}

Li, Jiangchao ^{[1
]}

Zhang, Qianqian ^{[1
]}

Lan, Tian ^{[1
]}

He, Xiaodong ^{[1
]}

Cao, Liu ^{[4
]}

Zhou, Jia ^{[5
]}

Geng, Jianguo ^{[3
]}

Wang, Lijing ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Vasc Biol Res Inst, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Gastrointestinal Surg, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

[3] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

[4] China Med Univ, Key Lab Med Cell Biol, Shen Yang City 110001, Liao Ning Provi, Peoples R China

[5] Univ Texas Med Branch, Chem Biol Program, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

来源：

ONCOTARGET | 2015年 / 6卷 / 09期

基金：

美国国家科学基金会;

关键词：

P-selectin; platelets; tumor growth; alpha IIb beta 3; talin1; IN-VIVO; METASTASIS FORMATION; CANCER GROWTH; ANGIOGENESIS; ACTIVATION; LEUKOCYTES; CARCINOMA; MODEL; INHIBITION; GPIIB/IIIA;

D O I：

10.18632/oncotarget.3164

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the beta 3 cytoplasmic tail. This activates alpha IIb beta 3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism.

引用

页码：6584 / 6596

页数：13

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