Rapid synthesis of 2,5-disubtituted 1,3,4-thiadiazoles under microwave irradiation

被引：49

作者：

Lebrini, M

Bentiss, F

Lagrenée, M

机构：

[1] ENSCL, CNRS, UMR 8012, Lab Cristallochim & Physicochim Solide, F-59652 Villeneuve Dascq, France

[2] Univ Chouaib Doukkali, Fac Sci, Lab Chim Coordinat & Analyt, El Jadida, Morocco

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 05期

关键词：

D O I：

10.1002/jhet.5570420538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5-disubstituted 1,3,4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by H-1, C-13 NMR, MS and elemental analysis.

引用

页码：991 / 994

页数：4

共 15 条

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MAZZONE G, 1982, FARMACO-ED SCI, V37, P685

[12] A NEW SYNTHESIS OF SYMMETRICAL 2,5-DIARYL-1,3,4-THIADIAZOLES [J].